Abstract：
Traumatic brain injury (TBI) is a leading cause of disability worldwide, with an estimated annual incidence of 27-69 million. TBI is a severe condition that can lead to high mortality rates and long-term cognitive, behavioral, and physical impairments in young adults. It is a significant public health concern due to the lack of effective treatments available. Quercetin, a natural flavonoid found in various fruits and vegetables, has demonstrated therapeutic potential with anti-inflammatory, antioxidant, and neuroprotective properties. Recently, some evidence has accentuated the ameliorating effects of quercetin on TBI. This review discusses quercetin\'s ability to reduce TBI-related damage by regulating many cellular and molecular pathways. Quercetin in vitro and in vivo studies exhibit promise in reducing inflammation, oxidative stress, apoptosis, and enhancing cognitive function post-TBI. Further clinical investigation into quercetin\'s therapeutic potential as a readily available adjuvant in the treatment of TBI is warranted in light of these findings. This review adds to our knowledge of quercetin\'s potential in treating TBI by clarifying its mechanisms of action.
摘要：
创伤性脑损伤（TBI）是全球残疾的主要原因，估计年发病率为27-69百万。TBI是一种严重的疾病，可能导致高死亡率和长期认知，行为，和年轻人的身体损伤。由于缺乏有效的治疗方法，这是一个重大的公共卫生问题。槲皮素,一种在各种水果和蔬菜中发现的天然类黄酮，已经证明了抗炎的治疗潜力，抗氧化剂，和神经保护特性。最近,一些证据强调了槲皮素对TBI的改善作用。本文综述了槲皮素通过调节多种细胞和分子途径减轻TBI相关损伤的能力。槲皮素的体外和体内研究显示出减少炎症的希望，氧化应激，凋亡，增强TBI后的认知功能。鉴于这些发现，有必要进一步临床研究槲皮素作为TBI治疗中一种现成的佐剂的治疗潜力。这篇综述通过阐明槲皮素的作用机制，增加了我们对槲皮素治疗TBI潜力的认识。
