Abstract：
OBJECTIVE: This research study was undertaken to investigate antimicrobial resistance patterns and the prevalence of hospital-acquired infections (HAIs). The study focuses on common microorganisms responsible for HAIs and explores emerging challenges posed by antimicrobial drug-resistant isolates.
METHODS: A comprehensive analysis of 123 patients with HAIs, hospitalized in surgical department and intensive care unit (ICU) at Imam Khomeini Hospital, Ilam, Iran, was conducted over a six-month period. Pathogenic bacterial isolates, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA), were isolated and subjected to antibiotic susceptibility testing.
RESULTS: The study findings revealed a significant prevalence of multidrug-resistant (MDR) isolates, of which 73.3% were MRSA. Notably, 6.7% of S. aureus isolates exhibited resistance to vancomycin, indicating the emergence of VRSA. Respiratory infections were identified as the most prevalent HAI, constituting 34.67% of cases, often arising from extended ICU stays and invasive surgical procedures. Furthermore, patients aged 60 and above, particularly those associated with MDR, exhibited higher vulnerability to HAI.
CONCLUSIONS: This research sheds light on the intricate interplay between drug resistance and HAI, highlighting the imperative role of rational antibiotic use and infection control in addressing this critical healthcare challenge.
METHODS: A comprehensive analysis of 123 patients with HAIs, hospitalized in surgical department and intensive care unit (ICU) at Imam Khomeini Hospital, Ilam, Iran, was conducted over a six-month period. Pathogenic bacterial isolates, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA), were isolated and subjected to antibiotic susceptibility testing.
RESULTS: The study findings revealed a significant prevalence of multidrug-resistant (MDR) isolates, of which 73.3% were MRSA. Notably, 6.7% of S. aureus isolates exhibited resistance to vancomycin, indicating the emergence of VRSA. Respiratory infections were identified as the most prevalent HAI, constituting 34.67% of cases, often arising from extended ICU stays and invasive surgical procedures. Furthermore, patients aged 60 and above, particularly those associated with MDR, exhibited higher vulnerability to HAI.
CONCLUSIONS: This research sheds light on the intricate interplay between drug resistance and HAI, highlighting the imperative role of rational antibiotic use and infection control in addressing this critical healthcare challenge.
摘要：
目的：本研究旨在调查抗菌药物耐药模式和医院获得性感染（HAIs）的流行情况。该研究的重点是负责HAIs的常见微生物，并探讨了抗微生物药物抗性分离株带来的新挑战。
方法：对123例HAIs患者进行综合分析，在伊玛目霍梅尼医院的外科和重症监护室（ICU）住院，伊兰,伊朗,进行了六个月的时间。病原菌分离株，包括耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素金黄色葡萄球菌（VRSA），被分离并接受抗生素药敏试验。
结果：研究结果表明，多重耐药（MDR）分离株的患病率很高，其中73.3%为MRSA。值得注意的是,6.7%的金黄色葡萄球菌分离株对万古霉素表现出耐药性，表明VRSA的出现。呼吸道感染被确定为最普遍的HAI，占病例的34.67%，通常由延长ICU住院时间和侵入性外科手术引起。此外，60岁及以上的病人，特别是那些与MDR相关的，对HAI表现出更高的脆弱性。
结论：这项研究揭示了耐药性与HAI之间复杂的相互作用，强调合理使用抗生素和控制感染在应对这一关键医疗挑战中的重要作用。
方法：对123例HAIs患者进行综合分析，在伊玛目霍梅尼医院的外科和重症监护室（ICU）住院，伊兰,伊朗,进行了六个月的时间。病原菌分离株，包括耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素金黄色葡萄球菌（VRSA），被分离并接受抗生素药敏试验。
结果：研究结果表明，多重耐药（MDR）分离株的患病率很高，其中73.3%为MRSA。值得注意的是,6.7%的金黄色葡萄球菌分离株对万古霉素表现出耐药性，表明VRSA的出现。呼吸道感染被确定为最普遍的HAI，占病例的34.67%，通常由延长ICU住院时间和侵入性外科手术引起。此外，60岁及以上的病人，特别是那些与MDR相关的，对HAI表现出更高的脆弱性。
结论：这项研究揭示了耐药性与HAI之间复杂的相互作用，强调合理使用抗生素和控制感染在应对这一关键医疗挑战中的重要作用。
