Abstract：
BACKGROUND: Increasing evidence suggests that autoimmune disorders and their immunomodulating medications may increase the risk of rhinosinusitis. The goal of this study is to determine if autoimmune and autoinflammatory diseases are associated with increased risk of chronic rhinosinusitis (CRS) in children.
METHODS: A retrospective case-control study of pediatric patients (age 2-18 years) seen in the West Virginia University Hospitals System in the past 10 years was performed. Cases were children with autoimmune or autoinflammatory diseases. Controls were children without any autoimmune or autoinflammatory disorders. Query of our electronic medical record (Epic) was performed using ICD-10 codes. Univariate (unadjusted) and multivariate (adjusted) logistic regression were used to calculate the strength of association of autoimmune or autoinflammatory disorders with CRS and the other airway disorders while adjusting for age, sex, and race.
RESULTS: 420582 pediatric patients were queried with mean age of 10.8 years (SD of 4.8, range of 2-18 years), and 47.9% being female. 1956 (0.5%) had autoimmune disorders and 293 (0.07%) had autoinflammatory disorders. Both autoimmune and autoinflammatory disorders increase the odds of having CRS in the unadjusted [OR = 3.36, p < 0.001 and 5.69, p < 0.001 for the respectively] and the adjusted [OR = 2.90, p < 0.001 and OR = 5.07, p < 0.001 respectively after adjusting for age, sex, and race] models.
CONCLUSIONS: Autoimmune and autoinflammatory disorders increase the risk of CRS and chronic rhinitis in children.
METHODS: A retrospective case-control study of pediatric patients (age 2-18 years) seen in the West Virginia University Hospitals System in the past 10 years was performed. Cases were children with autoimmune or autoinflammatory diseases. Controls were children without any autoimmune or autoinflammatory disorders. Query of our electronic medical record (Epic) was performed using ICD-10 codes. Univariate (unadjusted) and multivariate (adjusted) logistic regression were used to calculate the strength of association of autoimmune or autoinflammatory disorders with CRS and the other airway disorders while adjusting for age, sex, and race.
RESULTS: 420582 pediatric patients were queried with mean age of 10.8 years (SD of 4.8, range of 2-18 years), and 47.9% being female. 1956 (0.5%) had autoimmune disorders and 293 (0.07%) had autoinflammatory disorders. Both autoimmune and autoinflammatory disorders increase the odds of having CRS in the unadjusted [OR = 3.36, p < 0.001 and 5.69, p < 0.001 for the respectively] and the adjusted [OR = 2.90, p < 0.001 and OR = 5.07, p < 0.001 respectively after adjusting for age, sex, and race] models.
CONCLUSIONS: Autoimmune and autoinflammatory disorders increase the risk of CRS and chronic rhinitis in children.
摘要：
背景：越来越多的证据表明自身免疫性疾病及其免疫调节药物可能会增加鼻窦炎的风险。这项研究的目的是确定自身免疫性和自身炎症性疾病是否与儿童慢性鼻-鼻窦炎（CRS）的风险增加有关。
方法：对过去10年在西弗吉尼亚大学医院系统中看到的儿科患者（2-18岁）进行了回顾性病例对照研究。病例为患有自身免疫性或自身炎性疾病的儿童。对照组为无任何自身免疫或自身炎性疾病的儿童。使用ICD-10代码查询我们的电子病历（Epic）。使用单变量（未调整）和多变量（调整）逻辑回归来计算自身免疫性或自身炎症性疾病与CRS和其他气道疾病的关联强度，同时调整年龄，性别,和种族。
结果：420582名儿科患者的平均年龄为10.8岁（SD为4.8，范围为2-18岁），47.9%是女性。1956（0.5％）患有自身免疫性疾病，293（0.07％）患有自身炎症性疾病。自身免疫性和自身炎症性疾病都会增加未调整的[OR=3.36，p<0.001和5.69，p<0.001]和调整后的[OR=2.90，p<0.001和OR=5.07，p<0.001，分别在调整年龄后，性别,和种族]模型。
结论：自身免疫性疾病和自身炎症性疾病会增加儿童CRS和慢性鼻炎的风险。
方法：对过去10年在西弗吉尼亚大学医院系统中看到的儿科患者（2-18岁）进行了回顾性病例对照研究。病例为患有自身免疫性或自身炎性疾病的儿童。对照组为无任何自身免疫或自身炎性疾病的儿童。使用ICD-10代码查询我们的电子病历（Epic）。使用单变量（未调整）和多变量（调整）逻辑回归来计算自身免疫性或自身炎症性疾病与CRS和其他气道疾病的关联强度，同时调整年龄，性别,和种族。
结果：420582名儿科患者的平均年龄为10.8岁（SD为4.8，范围为2-18岁），47.9%是女性。1956（0.5％）患有自身免疫性疾病，293（0.07％）患有自身炎症性疾病。自身免疫性和自身炎症性疾病都会增加未调整的[OR=3.36，p<0.001和5.69，p<0.001]和调整后的[OR=2.90，p<0.001和OR=5.07，p<0.001，分别在调整年龄后，性别,和种族]模型。
结论：自身免疫性疾病和自身炎症性疾病会增加儿童CRS和慢性鼻炎的风险。
