%0 Journal Article
%T Association of autoimmune and autoinflammatory disorders with chronic rhinosinusitis in children.
%A Gabbireddy S
%A Shetty S
%A Coutinho D
%A Ramadan H
%A Makary C
%J Int J Pediatr Otorhinolaryngol
%V 181
%N 0
%D 2024 Jun 22
%M 38795462
%F 1.626
%R 10.1016/j.ijporl.2024.111988
%X <B>BACKGROUND: </B>Increasing evidence suggests that autoimmune disorders and their immunomodulating medications may increase the risk of rhinosinusitis. The goal of this study is to determine if autoimmune and autoinflammatory diseases are associated with increased risk of chronic rhinosinusitis (CRS) in children.<BR><B>METHODS: </B>A retrospective case-control study of pediatric patients (age 2-18 years) seen in the West Virginia University Hospitals System in the past 10 years was performed. Cases were children with autoimmune or autoinflammatory diseases. Controls were children without any autoimmune or autoinflammatory disorders. Query of our electronic medical record (Epic) was performed using ICD-10 codes. Univariate (unadjusted) and multivariate (adjusted) logistic regression were used to calculate the strength of association of autoimmune or autoinflammatory disorders with CRS and the other airway disorders while adjusting for age, sex, and race.<BR><B>RESULTS: </B>420582 pediatric patients were queried with mean age of 10.8 years (SD of 4.8, range of 2-18 years), and 47.9% being female. 1956 (0.5%) had autoimmune disorders and 293 (0.07%) had autoinflammatory disorders. Both autoimmune and autoinflammatory disorders increase the odds of having CRS in the unadjusted [OR = 3.36, p < 0.001 and 5.69, p < 0.001 for the respectively] and the adjusted [OR = 2.90, p < 0.001 and OR = 5.07, p < 0.001 respectively after adjusting for age, sex, and race] models.<BR><B>CONCLUSIONS: </B>Autoimmune and autoinflammatory disorders increase the risk of CRS and chronic rhinitis in children.