关键词: Cell cycle block Malignant tumors Therapeutic strategies Tumor dormancy Tumor metastasis

来  源:   DOI:10.1007/s12672-024-01049-2   PDF(Pubmed)

Abstract:
Tumor dormancy is a stage in the growth and development of malignant cells and is one of the biological characteristics of malignant cells. Complex transitions involving dormant tumor cells between quiescent and proliferative states pose challenges for tumor eradication. This paper explores the biological features and molecular mechanisms of tumor dormancy and highlights emerging therapies. The strategies discussed promise innovative clinical potential against malignant tumors. Understanding the mechanisms of dormancy can help provide valuable insights into the diagnosis and treatment of malignant tumors to advance the fight against this world problem.
摘要:
肿瘤休眠是恶性细胞生长和发育的一个阶段,是恶性细胞的生物学特征之一。涉及休眠肿瘤细胞在静止状态和增殖状态之间的复杂转变对肿瘤根除提出了挑战。本文探讨了肿瘤休眠的生物学特征和分子机制,并重点介绍了新兴的治疗方法。讨论的策略有望针对恶性肿瘤具有创新的临床潜力。了解休眠机制可以帮助为恶性肿瘤的诊断和治疗提供有价值的见解,以推进与这一世界问题的斗争。
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