Abstract：
OBJECTIVE: This study aims to analyze the clinicopathological characteristics and survival outcomes of tongue cancer in the pediatric population, a topic with limited existing data, using a population-based cohort.
METHODS: Pediatric patients diagnosed with tongue cancer from 1975 to 2018 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Survival rates were assessed using Kaplan-Meier analysis. Univariate survival analysis was conducted with the log-rank test, while multivariate analysis involved Cox proportional-hazards regression to identify factors influencing overall survival (OS). A predictive nomogram was developed based on Cox regression findings.
RESULTS: In total, 97 pediatric patients with tongue cancer were identified, with a median age at diagnosis of 15 years (range: 1-19 years). Tumors were classified as squamous cell carcinoma (45.4%), rhabdomyosarcoma (RMS) (13.4%), and others (41.2%). Of the patients, squamous cell carcinoma was more common in older children, whereas rhabdomyosarcoma was more common in younger children. The Cox proportional hazard regression revealed that histology and surgery were significant independent predictors of overall survival. The chance of death increased with no surgery. Moreover, patients with squamous cell carcinoma or rhabdomyosarcoma have a poorer survival percentage than patients with other subtypes.
CONCLUSIONS: Tongue cancer in children is rare and associated with poor survival outcomes. This study highlights the significance of tumor histology and surgical intervention in determining overall survival, offering valuable insights for clinical decision-making in pediatric tongue cancer.
METHODS: Pediatric patients diagnosed with tongue cancer from 1975 to 2018 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Survival rates were assessed using Kaplan-Meier analysis. Univariate survival analysis was conducted with the log-rank test, while multivariate analysis involved Cox proportional-hazards regression to identify factors influencing overall survival (OS). A predictive nomogram was developed based on Cox regression findings.
RESULTS: In total, 97 pediatric patients with tongue cancer were identified, with a median age at diagnosis of 15 years (range: 1-19 years). Tumors were classified as squamous cell carcinoma (45.4%), rhabdomyosarcoma (RMS) (13.4%), and others (41.2%). Of the patients, squamous cell carcinoma was more common in older children, whereas rhabdomyosarcoma was more common in younger children. The Cox proportional hazard regression revealed that histology and surgery were significant independent predictors of overall survival. The chance of death increased with no surgery. Moreover, patients with squamous cell carcinoma or rhabdomyosarcoma have a poorer survival percentage than patients with other subtypes.
CONCLUSIONS: Tongue cancer in children is rare and associated with poor survival outcomes. This study highlights the significance of tumor histology and surgical intervention in determining overall survival, offering valuable insights for clinical decision-making in pediatric tongue cancer.
摘要：
目的：本研究旨在分析儿童人群舌癌的临床病理特征和生存结局，现有数据有限的主题，使用基于人群的队列。
方法：从监测中确定了1975年至2018年诊断为舌癌的儿科患者，流行病学,和结束结果(SEER)数据库。使用Kaplan-Meier分析评估生存率。单变量生存分析采用对数秩检验,而多变量分析采用Cox比例风险回归来确定影响总生存期(OS)的因素.基于Cox回归结果开发了预测列线图。
结果：总计，97名儿童舌癌患者被确定，诊断时的中位年龄为15岁（范围：1-19岁）。肿瘤分类为鳞状细胞癌（45.4%），横纹肌肉瘤（RMS）（13.4%），和其他（41.2%）。在患者中，鳞状细胞癌在年龄较大的儿童中更常见，而横纹肌肉瘤在年龄较小的儿童中更为常见。Cox比例风险回归显示，组织学和手术是总生存率的重要独立预测因素。没有手术的死亡机会增加。此外，鳞状细胞癌或横纹肌肉瘤患者的生存率比其他亚型患者低.
结论：儿童舌癌是罕见的，与不良的生存结果相关。这项研究强调了肿瘤组织学和手术干预在确定总生存期中的意义。为小儿舌癌的临床决策提供有价值的见解。
方法：从监测中确定了1975年至2018年诊断为舌癌的儿科患者，流行病学,和结束结果(SEER)数据库。使用Kaplan-Meier分析评估生存率。单变量生存分析采用对数秩检验,而多变量分析采用Cox比例风险回归来确定影响总生存期(OS)的因素.基于Cox回归结果开发了预测列线图。
结果：总计，97名儿童舌癌患者被确定，诊断时的中位年龄为15岁（范围：1-19岁）。肿瘤分类为鳞状细胞癌（45.4%），横纹肌肉瘤（RMS）（13.4%），和其他（41.2%）。在患者中，鳞状细胞癌在年龄较大的儿童中更常见，而横纹肌肉瘤在年龄较小的儿童中更为常见。Cox比例风险回归显示，组织学和手术是总生存率的重要独立预测因素。没有手术的死亡机会增加。此外，鳞状细胞癌或横纹肌肉瘤患者的生存率比其他亚型患者低.
结论：儿童舌癌是罕见的，与不良的生存结果相关。这项研究强调了肿瘤组织学和手术干预在确定总生存期中的意义。为小儿舌癌的临床决策提供有价值的见解。
