Abstract：
UNASSIGNED: Common mental disorders (CMD) are associated with impaired frontal excitatory/inhibitory (E/I) balance and reduced grey matter volume (GMV). Larger GMV (in the areas that are implicated in CMD-pathology) and improved CMD-symptomatology have been observed in individuals who adhere to high quality diets. Moreover, preclinical studies have shown altered neurometabolites (primarily gamma-aminobutyric acid: GABA and glutamate: GLU) in relation to diet quality. However, neurochemical correlates of diet quality and how these neurobiological changes are associated with CMD and with its transdiagnostic factor, rumination, is unknown in humans. Therefore, in this study, we examined the associations between diet quality and frontal cortex neuro-chemistry and structure, as well as CMD and rumination in humans.
UNASSIGNED: Thirty adults were classified into high and low diet quality groups and underwent 1H-MRS to measure medial prefrontal cortex (mPFC) metabolite concentrations and volumetric imaging to measure GMV.
UNASSIGNED: Low (vs High) diet quality group had reduced mPFC-GABA and elevated mPFC-GLU concentrations, as well as reduced right precentral gyrus (rPCG) GMV. However, CMD and rumination were not associated with diet quality. Notably, we observed a significant negative correlation between rumination and rPCG-GMV and a marginally significant association between rumination and mPFC-GLU concentrations. There was also a marginally significant association between mPFC-GLU concentrations and rPCG-GMV.
UNASSIGNED: Adhering to unhealthy dietary patterns may be associated with compromised E/I balance, and this could affect GMV, and subsequently, rumination.
UNASSIGNED: Thirty adults were classified into high and low diet quality groups and underwent 1H-MRS to measure medial prefrontal cortex (mPFC) metabolite concentrations and volumetric imaging to measure GMV.
UNASSIGNED: Low (vs High) diet quality group had reduced mPFC-GABA and elevated mPFC-GLU concentrations, as well as reduced right precentral gyrus (rPCG) GMV. However, CMD and rumination were not associated with diet quality. Notably, we observed a significant negative correlation between rumination and rPCG-GMV and a marginally significant association between rumination and mPFC-GLU concentrations. There was also a marginally significant association between mPFC-GLU concentrations and rPCG-GMV.
UNASSIGNED: Adhering to unhealthy dietary patterns may be associated with compromised E/I balance, and this could affect GMV, and subsequently, rumination.
摘要：
■常见的精神障碍（CMD）与额叶兴奋/抑制（E/I）平衡受损和灰质体积（GMV）减少有关。在坚持高质量饮食的个体中观察到较大的GMV(在涉及CMD病理学的区域中)和改善的CMD症状学。此外，临床前研究表明，与饮食质量有关的神经代谢产物（主要是γ-氨基丁酸：GABA和谷氨酸：GLU）发生了变化。然而,饮食质量的神经化学相关性以及这些神经生物学变化如何与CMD及其诊断因子相关，沉思，在人类中是未知的。因此,在这项研究中，我们检查了饮食质量与额叶皮质神经化学和结构之间的关系，以及人类的CMD和反思。
■将30名成年人分为高和低饮食质量组，并进行1H-MRS以测量内侧前额叶皮层（mPFC）代谢物浓度和体积成像以测量GMV。
■低（与高）饮食质量组mPFC-GABA降低，mPFC-GLU浓度升高，以及减少的右中央前回（rPCG）GMV。然而,CMD和反蚀与饮食质量无关。值得注意的是,我们观察到反刍动物与rPCG-GMV之间存在显著负相关,反刍动物与mPFC-GLU浓度之间存在轻微显著关联.在mPFC-GLU浓度和rPCG-GMV之间也存在轻微显著的关联。
■坚持不健康的饮食模式可能与E/I平衡受损有关，这可能会影响GMV,随后,沉思。
■将30名成年人分为高和低饮食质量组，并进行1H-MRS以测量内侧前额叶皮层（mPFC）代谢物浓度和体积成像以测量GMV。
■低（与高）饮食质量组mPFC-GABA降低，mPFC-GLU浓度升高，以及减少的右中央前回（rPCG）GMV。然而,CMD和反蚀与饮食质量无关。值得注意的是,我们观察到反刍动物与rPCG-GMV之间存在显著负相关,反刍动物与mPFC-GLU浓度之间存在轻微显著关联.在mPFC-GLU浓度和rPCG-GMV之间也存在轻微显著的关联。
■坚持不健康的饮食模式可能与E/I平衡受损有关，这可能会影响GMV,随后,沉思。
