PDF(Pubmed)
Abstract：
Acute mountain sickness (AMS) is a common ailment in high-altitude areas caused by the body\'s inadequate adaptation to low-pressure, low-oxygen environments, leading to organ edema, oxidative stress, and impaired intestinal barrier function. The gastrointestinal tract, being the first to be affected by ischemia and hypoxia, is highly susceptible to injury. This study investigates the role of Lactobacillus delbrueckii subsp. bulgaricus in alleviating acute hypoxic-induced intestinal and tissue damage from the perspective of daily consumed lactic acid bacteria. An acute hypoxia mouse model was established to evaluate tissue injury, oxidative stress, inflammatory responses, and intestinal barrier function in various groups of mice. The results indicate that strain 4L3 significantly mitigated brain and lung edema caused by hypoxia, improved colonic tissue damage, and effectively increased the content of tight junction proteins in the ileum, reducing ileal permeability and alleviating mechanical barrier damage in the intestines due to acute hypoxia. Additionally, 4L3 helped to rebalance the intestinal microbiota. In summary, this study found that Lactobacillus delbrueckii subsp. bulgaricus strain 4L3 could alleviate acute intestinal damage caused by hypoxia, thereby reducing hypoxic stress. This suggests that probiotic lactic acid bacteria that exert beneficial effects in the intestines may alleviate acute injury under hypoxic conditions in mice, offering new insights for the prevention and treatment of AMS.
摘要：
急性高山病(AMS)是高海拔地区人体对低压不适应引起的常见疾病,低氧环境,导致器官水肿，氧化应激，肠屏障功能受损。胃肠道，首先受到缺血和缺氧的影响，极易受伤。这项研究调查了德氏乳杆菌亚种的作用。保加利亚从每日消耗的乳酸菌的角度减轻急性缺氧诱导的肠道和组织损伤。建立急性缺氧小鼠模型评价组织损伤,氧化应激，炎症反应，各组小鼠的肠屏障功能。结果表明，菌株4L3显著减轻缺氧引起的脑和肺水肿，改善结肠组织损伤，并有效地增加了回肠中紧密连接蛋白的含量，降低回肠通透性，减轻急性缺氧引起的肠道机械屏障损伤。此外,4L3有助于重新平衡肠道微生物群。总之,本研究发现德氏乳杆菌亚种。保加利亚菌株4L3可以减轻缺氧引起的急性肠道损伤,从而减少低氧应激。这表明在肠道中发挥有益作用的益生菌乳酸菌可以减轻小鼠在缺氧条件下的急性损伤，为AMS的预防和治疗提供新的见解。
