PDF(Pubmed)
Abstract：
Since the beginning of the COVID-19 pandemic, vitamin D has attracted interest due to its immunomodulatory properties. Numerous studies show a correlation between vitamin D levels and COVID-19 cases and mortality. Therefore, we conducted a meta-analysis in order to assess the relationship between vitamin D3 supplementation and COVID-19 severity. We included 13 randomized clinical trials that contained the analyzed endpoints: length of COVID-19 hospitalization, number of intensive care unit (ICU) admissions, length of stay in the ICU, number of cases requiring any supplemental oxygenation, duration of any supplemental oxygenation, number of overall mortality and number of deaths associated with COVID-19. The relative risk with 95% confidence interval (CI) and the mean difference with 95% CI were calculated to compare the effect. A random effects model was used to calculate effect sizes. Our meta-analysis showed a positive effect of vitamin D3 supplementation on ICU admission (RR = 0.73; 95% CI [0.57; 0.95], p = 0.02, I2 = 19.6%) and mortality associated with COVID-19 among patients (RR = 0.56; 95% CI [0.34; 0.91]; p = 0.02; I2 = 0%). Vitamin D3 supplementation may potentially reduce the risk of ICU admission and death associated with COVID-19.
摘要：
自从COVID-19大流行开始以来，维生素D由于其免疫调节特性而引起了人们的兴趣。大量研究表明，维生素D水平与COVID-19病例和死亡率之间存在相关性。因此,我们进行了一项荟萃分析,以评估补充维生素D3与COVID-19严重程度之间的关系.我们纳入了13项随机临床试验，其中包含分析的终点：COVID-19住院时间，重症监护病房(ICU)的入院人数，在ICU的停留时间,需要任何补充氧合的病例数量，任何补充充氧的持续时间，与COVID-19相关的总死亡率和死亡人数。计算95%置信区间(CI)的相对危险度和95%CI的平均差来比较效果。使用随机效应模型来计算效应大小。我们的荟萃分析显示补充维生素D3对ICU入院有积极影响(RR=0.73;95%CI[0.57;0.95],p=0.02，I2=19.6%），患者的死亡率与COVID-19相关(RR=0.56；95%CI[0.34；0.91]；p=0.02；I2=0%)。补充维生素D3可能会降低入住ICU和与COVID-19相关的死亡风险。
