PDF(Pubmed)
Abstract：
As antibiotic resistance increasingly undermines traditional infection management strategies, there is a critical demand for innovative wound care solutions that address these emerging challenges. This study introduces a novel antibacterial wound dressing based on Cross-Linked Pullulan (Pul) and Polyhexamethylene Biguanide (PHMB) for enhanced wound management and infection control. The dressing\'s adsorption rate reached 200% of its original weight within 30 min, exceeded 300% after 5 h, and exhibited significant non-Newtonian fluid properties. The dressings were able to release the loaded medication completely within 20 min; additionally, the dressing demonstrated significant antibacterial activity against a broad spectrum of bacteria. Significantly, the therapeutic effects of the Pul-PHMB/GP dressing were evaluated in a mouse model. Compared to untreated wounds, wounds treated with Pul-PHMB/GP exhibited a significant gelation process within 5 min post-treatment and showed a significant increase in wound healing rate within 12 days. This powder preparation overcomes the limitations associated with liquid and gel dressings, notably in storage and precise application, preventing the premature expansion or dissolution often caused by PHMB in high-humidity environments. The powder form can transform into a gel upon contact with wound exudate, ensuring accurate coverage of irregular wounds, such as those from burns or pressure sores, and offers excellent chemical and physical stability in a dry state, which facilitates storage and transport. This makes the dressing particularly suitable for emergency medical care and precision therapy, significantly improving the efficiency and adaptability of wound treatment and providing robust support for clinical treatments and emergency responses.
摘要：
随着抗生素耐药性日益破坏传统的感染管理策略，有一个关键的需求，以应对这些新出现的挑战创新的伤口护理解决方案。这项研究介绍了一种基于交联普鲁兰（Pul）和聚六亚甲基双胍（PHMB）的新型抗菌伤口敷料，用于增强伤口管理和感染控制。30min内敷料的吸附率达到原重的200%,5小时后超过300%，并表现出显著的非牛顿流体性质。敷料能够在20分钟内完全释放装载的药物；此外，敷料对广谱细菌表现出显著的抗菌活性。重要的是,在小鼠模型中评估了Pul-PHMB/GP敷料的治疗效果.与未经治疗的伤口相比，用Pul-PHMB/GP治疗的伤口在治疗后5分钟内表现出明显的凝胶化过程，并且在12天内伤口愈合率显着增加。这种粉末制剂克服了与液体和凝胶敷料相关的限制，特别是在存储和精确应用中，防止在高湿度环境中通常由PHMB引起的过早膨胀或溶解。粉末形式可以在与伤口渗出物接触时转化为凝胶，确保不规则伤口的准确覆盖，如烧伤或压疮，并在干燥状态下提供优异的化学和物理稳定性，便于储存和运输。这使得敷料特别适用于紧急医疗护理和精确治疗，显着提高伤口治疗的效率和适应性，为临床治疗和应急反应提供有力支持。
