PDF(Pubmed)
Abstract：
In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, the healthcare landscape is constantly evolving, necessitating the continual development of innovative therapeutic approaches and drug delivery systems (DDSs). DDSs play a pivotal role in enhancing treatment efficacy, minimizing adverse effects, and optimizing patient compliance. Among these, nanotechnology-driven delivery approaches have garnered significant attention due to their unique properties, such as improved solubility, controlled release, and targeted delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., offer versatile platforms for drug delivery and tissue engineering applications. Additionally, biopolymer-based DDSs hold immense promise, leveraging natural or synthetic biopolymers to encapsulate drugs and enable targeted and controlled release. These systems offer numerous advantages, including biocompatibility, biodegradability, and low immunogenicity. The utilization of polysaccharides, polynucleotides, proteins, and polyesters as biopolymer matrices further enhances the versatility and applicability of DDSs. Moreover, substances with antioxidative properties have emerged as key players in combating oxidative stress-related diseases, offering protection against cellular damage and chronic illnesses. The development of biopolymer-based nanoformulations with antioxidative properties represents a burgeoning research area, with a substantial increase in publications in recent years. This review provides a comprehensive overview of the recent developments within this area over the past five years. It discusses various biopolymer materials, fabrication techniques, stabilizers, factors influencing degradation, and drug release. Additionally, it highlights emerging trends, challenges, and prospects in this rapidly evolving field.
摘要：
近年来,具有抗氧化性能的基于生物聚合物的纳米药物递送系统在药物研究领域得到了广泛的关注。这些系统为靶向和受控药物递送提供了有希望的策略，同时还提供了可以减轻氧化应激相关疾病的抗氧化作用。一般来说,医疗保健领域在不断发展，需要不断开发创新的治疗方法和药物递送系统(DDS)。DDS在提高治疗疗效方面发挥着关键作用，尽量减少不利影响，优化患者依从性。其中,纳米技术驱动的递送方法由于其独特的性质而受到了极大的关注，如提高溶解度，控释,和有针对性的交付。纳米材料,包括纳米粒子,纳米胶囊，纳米管,等。,为药物输送和组织工程应用提供多功能平台。此外,基于生物聚合物的DDS拥有巨大的前景，利用天然或合成的生物聚合物来封装药物并实现靶向和受控释放。这些系统提供了许多优点，包括生物相容性,生物降解性，低免疫原性。多糖的利用，多核苷酸,蛋白质，和聚酯作为生物聚合物基质进一步增强了DDS的多功能性和适用性。此外，具有抗氧化特性的物质已成为对抗氧化应激相关疾病的关键参与者，提供保护，防止细胞损伤和慢性疾病。具有抗氧化性能的基于生物聚合物的纳米制剂的开发代表了一个新兴的研究领域，近年来出版物大幅增加。本审查全面概述了过去五年该领域的最新发展。它讨论了各种生物聚合物材料，制造技术，稳定剂,影响降解的因素，和药物释放。此外,它突出了新兴趋势，挑战,以及这个快速发展的领域的前景。
