PDF(Pubmed)
Abstract：
Since 2011, South Korea has implemented biannual vaccinations against foot-and-mouth disease (FMD) and recently, lumpy skin disease (LSD), to mitigate the spread of transboundary animal diseases. However, due to past adverse reactions, potentially linked to acute phase responses from FMD vaccinations, there is hesitancy among Korean livestock farmers regarding new strategies for simultaneous vaccinations against both FMD and LSD. This study was conducted to assess possible adverse reactions to the LSD vaccination by analyzing acute phase proteins (APPs) in three groups: cows vaccinated against FMD (G1-FMDV), LSD (G2-LSDV), and both (G3-FMDV/LSDV). In G1-FMDV, APP levels peaked on day 3 post-vaccination (p < 0.001) and returned to baseline. In G2-LSDV, APP levels increased gradually, peaking on day 10 post-vaccination. In G3-FMDV/LSDV, APP levels peaked on day 3 post-vaccination and remained high until day 10 (p < 0.001). These results indicate that LSD vaccines trigger a later immune response compared to FMD vaccines, possibly due to different adjuvants. Therefore, a longer follow-up period for monitoring adverse reactions to LSD vaccinations may be required to understand and mitigate potential risks.
摘要：
自2011年以来，韩国实施了每两年一次的口蹄疫（FMD）疫苗接种，最近，肿块性皮肤病（LSD），以减轻跨界动物疾病的传播。然而,由于过去的不良反应，可能与口蹄疫疫苗接种的急性期反应有关，对于同时接种口蹄疫和LSD疫苗的新策略，韩国畜牧业农民犹豫不决。本研究通过分析三组的急性期蛋白（APP）来评估LSD疫苗接种可能的不良反应：接种FMD（G1-FMDV）的奶牛，LSD(G2-LSDV),和两者（G3-FMDV/LSDV）。在G1-FMDV中，APP水平在疫苗接种后第3天达到峰值(p<0.001)并返回基线。在G2-LSDV中，APP水平逐渐提高，疫苗接种后第10天达到峰值。在G3-FMDV/LSDV中，APP水平在疫苗接种后第3天达到峰值,并在第10天保持较高(p<0.001)。这些结果表明，与FMD疫苗相比，LSD疫苗引发的免疫反应较晚，可能是由于不同的佐剂。因此,可能需要较长的随访时间来监测LSD疫苗接种的不良反应,以了解和减轻潜在风险.
