PDF(Pubmed)
Abstract：
Hepatitis B and C viruses (HBV and HCV) are the leading causes of end-stage liver disease worldwide. Although there is a potent vaccine against HBV, many new infections are recorded annually, especially in poorly resourced places which have lax vaccination policies. Again, as HBV has no cure and chronic infection is lifelong, vaccines cannot help those already infected. Studies to thoroughly understand the HBV biology and pathogenesis are limited, leaving much yet to be understood about the genomic features and their role in establishing and maintaining infection. The current knowledge of the impact on disease progression and response to treatment, especially in hyperendemic regions, is inadequate. This calls for in-depth studies on viral biology, mainly for the purposes of coming up with better management strategies for infected people and more effective preventative measures for others. This information could also point us in the direction of a cure. Here, we discuss the progress made in understanding the genomic basis of viral activities leading to the complex interplay of the virus and the host, which determines the outcome of HBV infection as well as the impact of coinfections.
摘要：
乙型肝炎和丙型肝炎病毒（HBV和HCV）是全球终末期肝病的主要原因。虽然有一种针对HBV的有效疫苗，每年都有许多新的感染记录，尤其是在资源匮乏的地方，疫苗接种政策不严。再一次,由于HBV无法治愈，慢性感染是终身的，疫苗不能帮助那些已经感染的人。深入了解HBV生物学和发病机制的研究是有限的，关于基因组特征及其在建立和维持感染中的作用，还有很多尚待了解。对疾病进展和治疗反应的影响的当前知识，尤其是在高流行地区，是不够的。这就需要深入研究病毒生物学,主要目的是为感染者提出更好的管理策略，为他人提出更有效的预防措施。这些信息也可以为我们指明治愈的方向。这里,我们讨论了在理解导致病毒和宿主复杂相互作用的病毒活动的基因组基础方面取得的进展，这决定了HBV感染的结果以及合并感染的影响。
