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Abstract：
Background and Objective: Sealant application is a proven method to prevent occlusal caries; however, long-term studies on this topic are scarce. This study aimed to assess the survival rate and clinical effectiveness of glass ionomer cement (GIC) and resin-based sealants (RBSs) on second permanent molars over a long-term follow-up period. Materials and methods: Sixteen patients aged 11-13 years with all four completely erupted permanent second molars were enrolled in the study. All patients attended 1-year and 3-year follow-ups; however, one participant did not respond after 10 years and was excluded from the final analyses. The oral health status evaluation was based on WHO criteria. A total of 32 teeth received an RBS (Clinpro), and a further 32 teeth were sealed with GIC (Fuji IX). The sealant retention was determined according to the Kilpatrick criteria after 1 year, 3 years, and 10 years, respectively. Statistical analysis included a chi-square test, the Kaplan-Meier method, and the Cox proportional hazard model. Results: At baseline, seven boys and eight girls participated in the study, with a mean age of 12.3 ± 0.9 years. The 1-year follow-up results revealed that 90% of the RBSs and 43.3% of the GIC sealants were completely retained, and no caries lesions were recorded (p = 0.01). The 3-year follow-up results showed that 23.3% of the RBSs and 0% of the GIC sealants demonstrated complete retention (p = 0.034). Moreover, 10.0% of the occlusal surfaces in the RBS group and 13.3% of the occlusal surfaces in the GIC group were filled (p > 0.05). A total of 6.7% of the RBSs showed complete retention. One-third of the sealed teeth (30.0% of the teeth sealed with RBSs and 36.7% of teeth applied with GIC) were filled after 10 years. The Kaplan-Meier analysis demonstrated a higher survival rate in the RBS group when compared with the GIC over the entire follow-up period (p = 0.001). Conclusions: Although the survival rate of RBSs was higher than GIC sealants, their effectiveness in preventing fissure caries in permanent second molars did not differ significantly over a 10-year follow-up.
摘要：
背景和目的：密封剂的应用是一种行之有效的预防咬合龋齿的方法；然而，关于这一主题的长期研究很少。这项研究旨在评估长期随访期间玻璃离聚物水泥（GIC）和树脂基密封剂（RBS）对第二恒磨牙的存活率和临床有效性。材料和方法：本研究招募了16名年龄在11-13岁之间的患者，所有四个永久性第二磨牙都完全爆发。所有患者都接受了1年和3年的随访；然而，一名参与者在10年后没有反应,因此被排除在最终分析之外.口腔健康状况评估基于WHO标准。共有32颗牙齿接受了RBS（Clinpro），用GIC（富士IX）密封了另外32颗牙齿。密封剂保留率根据Kilpatrick标准在1年后测定,3年,10年,分别。统计分析包括卡方检验，Kaplan-Meier方法,和Cox比例风险模型。结果：在基线，七个男孩和八个女孩参加了这项研究，平均年龄12.3±0.9岁。1年的随访结果显示，90%的RBS和43.3%的GIC密封剂被完全保留，无龋齿病变记录（p=0.01）。3年的随访结果表明，23.3％的RBS和0％的GIC密封剂表现出完全保留（p=0.034）。此外，RBS组10.0%的咬合面和GIC组13.3%的咬合面被填充(p>0.05)。总共6.7%的RBS显示完全保留。10年后，三分之一的密封牙齿（30.0％的牙齿用RBS密封，36.7％的牙齿使用GIC）被填充。Kaplan-Meier分析显示，在整个随访期间，与GIC相比，RBS组的生存率更高（p=0.001）。结论：尽管RBSs的存活率高于GIC密封剂，在10年的随访中,它们在预防永久性第二磨牙裂龋方面的有效性没有显著差异.
