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Abstract：
Investigating the biophysiological substrates of psychiatric illnesses is of great interest to our understanding of disorders\' etiology, the identification of reliable biomarkers, and potential new therapeutic avenues. Schizophrenia represents a consolidated model of γ alterations arising from the aberrant activity of parvalbumin-positive GABAergic interneurons, whose dysfunction is associated with perineuronal net impairment and neuroinflammation. This model of pathogenesis is supported by molecular, cellular, and functional evidence. Proof for alterations of γ oscillations and their underlying mechanisms has also been reported in bipolar disorder and represents an emerging topic for major depressive disorder. Although evidence from animal models needs to be further elucidated in humans, the pathophysiology of γ-band alteration represents a common denominator for different neuropsychiatric disorders. The purpose of this narrative review is to outline a framework of converging results in psychiatric conditions characterized by γ abnormality, from neurochemical dysfunction to alterations in brain rhythms.
摘要：
研究精神疾病的生物生理学基础对我们理解疾病的病因学非常有意义。识别可靠的生物标志物，和潜在的新的治疗途径。精神分裂症代表了由小白蛋白阳性GABA能中间神经元异常活性引起的γ改变的综合模型，其功能障碍与神经周网状损伤和神经炎症有关。这种发病机制模型得到了分子支持，细胞，和功能性证据。在双相情感障碍中也报道了γ振荡改变及其潜在机制的证据，并且代表了重度抑郁症的新兴主题。尽管来自动物模型的证据需要在人类中进一步阐明，γ-带改变的病理生理学代表了不同神经精神疾病的共同点。这篇叙述性综述的目的是概述在以γ异常为特征的精神病中收敛结果的框架，从神经化学功能障碍到大脑节律的改变。
