PDF(Pubmed)
Abstract：
Background: Lipedema is a subcutaneous adipose tissue disorder characterized by increased pathological adipocytes mainly in the extremities. Vitamin D is stored in adipocytes, and serum levels inversely correlate with BMI. As adipocytes are removed during liposuction, lipedema patients might be prone to further substantial vitamin D loss while their levels are already decreased. Therefore, we examined the effect of liposuction on perioperative serum 25-hydroxyvitamin D levels. Methods: In patients undergoing lipedema liposuction, blood samples were obtained pre- and postoperatively. Statistical analyses were performed to correlate the volume of lipoaspirate, patients\' BMI and number of sessions to vitamin D levels. Results: Overall, 213 patients were analyzed. Mean liposuction volume was 6615.33 ± 3884.25 mL, mean BMI was 32.18 ± 7.26 kg/m2. mean preoperative vitamin D levels were 30.1 ± 14.45 ng/mL (borderline deficient according to the endocrine society) and mean postoperative vitamin D levels were 21.91 ± 9.18 ng/mL (deficient). A significant decrease in serum vitamin D was seen in our patients (p < 0.001) of mean 7.83 ng/mL. The amount of vitamin D loss was not associated with BMI or aspiration volume in our patients (p > 0.05). Interestingly, vitamin D dynamics showed a steady drop regardless of volume aspirated or preoperative levels. Conclusions: Many lipedema patients have low vitamin D levels preoperatively. Liposuction significantly reduced these levels additionally, regardless of aspirated volume or BMI. However, vitamin D loss was constant and predictable; thus, patients at risk are easily identified. Overall, lipedema patients undergoing liposuction are prone to vitamin D deficiency, and the long-term effects in this population are currently unknown.
摘要：
背景：脂水肿是一种以四肢脂肪细胞增多为特征的皮下脂肪组织疾病。维生素D储存在脂肪细胞中，血清水平与BMI呈负相关。由于脂肪细胞在吸脂术中被去除，脂水肿患者可能倾向于进一步大量的维生素D损失，而他们的水平已经下降。因此,我们研究了吸脂术对围手术期血清25-羟维生素D水平的影响.方法：在接受脂水肿吸脂术的患者中，术前和术后采集血样.进行统计分析以关联脂肪抽吸物的体积，患者的BMI和维生素D水平的会议次数。结果：总体而言，对213例患者进行分析。平均吸脂体积为6615.33±3884.25mL，平均BMI为32.18±7.26kg/m2。术前平均维生素D水平为30.1±14.45ng/mL(根据内分泌社会的临界缺乏),术后平均维生素D水平为21.91±9.18ng/mL(缺乏).在我们的患者中，血清维生素D显着降低（p<0.001），平均为7.83ng/mL。在我们的患者中，维生素D的丢失量与BMI或误吸量无关（p>0.05）。有趣的是,无论吸入量或术前水平如何,维生素D动力学均显示稳定下降.结论：许多脂肪水肿患者术前维生素D水平较低。此外，吸脂术显著降低了这些水平，无论吸气量或BMI。然而,维生素D的损失是恒定且可预测的；因此，有风险的患者很容易被识别。总的来说,接受吸脂术的患者容易缺乏维生素D，对这一人群的长期影响目前尚不清楚。
