PDF(Pubmed)
Abstract：
Bone mechanotransduction is a critical process during skeletal development in embryogenesis and organogenesis. At the same time, the type and level of mechanical loading regulates bone remodeling throughout the adult life. The aberrant mechanosensing of bone cells has been implicated in the development and progression of bone loss disorders, but also in the bone-specific aspect of other clinical entities, such as the tumorigenesis of solid organs. Novel treatment options have come into sight that exploit the mechanosensitivity of osteoblasts, osteocytes, and chondrocytes to achieve efficient bone regeneration. In this regard, runt-related transcription factor 2 (Runx2) has emerged as a chief skeletal-specific molecule of differentiation, which is prominent to induction by mechanical stimuli. Polycystins represent a family of mechanosensitive proteins that interact with Runx2 in mechano-induced signaling cascades and foster the regulation of alternative effectors of mechanotransuction. In the present narrative review, we employed a PubMed search to extract the literature concerning Runx2, polycystins, and their association from 2000 to March 2024. The keywords stated below were used for the article search. We discuss recent advances regarding the implication of Runx2 and polycystins in bone remodeling and regeneration and elaborate on the targeting strategies that may potentially be applied for the treatment of patients with bone loss diseases.
摘要：
骨机械转导是胚胎发生和器官发生中骨骼发育的关键过程。同时,机械负荷的类型和水平在整个成人生活中调节骨重建。骨细胞的异常机械传感与骨丢失疾病的发展和进展有关。而且在其他临床实体的骨骼特异性方面，如实体器官的肿瘤发生。新的治疗选择已经出现，利用成骨细胞的机械敏感性，骨细胞,和软骨细胞，以实现有效的骨再生。在这方面,runt相关转录因子2（Runx2）已成为主要的骨骼特异性分化分子，这对于机械刺激的诱导是突出的。多囊藻毒素代表机械敏感性蛋白家族，在机械诱导的信号级联中与Runx2相互作用，并促进机械抽吸的替代效应物的调节。在当前的叙述回顾中，我们采用PubMed搜索来提取有关Runx2，多囊素，和他们的协会从2000年到2024年3月。下面陈述的关键词用于文章搜索。我们讨论了有关Runx2和多囊藻毒素在骨重建和再生中的作用的最新进展，并详细阐述了可能用于治疗骨丢失疾病患者的靶向策略。
