PDF(Pubmed)
Abstract：
The protozoan parasite, Toxoplasma gondii, has been linked to several psychiatric disorders, including schizophrenia. The aim of this study was to assess the prevalence of T. gondii IgG antibodies and risk factors associated with seroprevalence in patients diagnosed with schizophrenia. This seroepidemiological study assessed 196 participants, divided into two groups. The study group consisted of 98 schizophrenic patients and was matched with 98 healthy blood donors. A questionnaire was used to gather information regarding potential risk factors associated with T. gondii seroprevalence. Results revealed a higher seroprevalence of T. gondii IgG antibodies in schizophrenic patients (69.39%, 68/98) when compared to healthy controls (51.02%, 50/98) (OR: 2.18; 95% CI: 1.21-3.9; p = 0.01). Patients with schizophrenia who consumed raw or undercooked meat (80.65%, 25/31) (OR: 3.75; 95% CI: 1.25-11.21, p = 0.02) and those with a lower educational level (77.59%, 45/58) (OR: 3.5; 95% CI: 1.59-7.54, p = 0.002) presented increased T. gondii seropositivity rates versus their control counterparts. Our findings indicate a high T. gondii IgG seroprevalence in patients diagnosed with schizophrenia compared to healthy blood donors. Factors associated with T. gondii seroprevalence were consumption of raw or uncooked meat and a lower educational attainment. This study provided the first data regarding the potential risk factors for toxoplasmosis in Romanian patients diagnosed with schizophrenia and may serve as a foundation for future research and the development of preventive strategies.
摘要：
原生动物寄生虫,弓形虫,与几种精神疾病有关，包括精神分裂症.这项研究的目的是评估诊断为精神分裂症的患者中弓形虫IgG抗体的患病率和与血清阳性率相关的危险因素。这项血清流行病学研究评估了196名参与者，分为两组。研究组由98名精神分裂症患者组成，并与98名健康献血者相匹配。使用问卷收集与弓形虫血清阳性率相关的潜在危险因素的信息。结果显示精神分裂症患者弓形虫IgG抗体的血清阳性率较高（69.39%，68/98）与健康对照组（51.02%，50/98）（OR：2.18；95%CI：1.21-3.9；p=0.01）。精神分裂症患者食用生肉或未煮熟的肉（80.65％，25/31）（OR：3.75；95％CI：1.25-11.21，p=0.02）和受教育程度较低的人（77.59％，45/58）（OR：3.5；95％CI：1.59-7.54，p=0.002）与对照组相比，弓形虫血清阳性率增加。我们的发现表明，与健康献血者相比，精神分裂症患者的弓形虫IgG血清阳性率较高。与弓形虫血清阳性率相关的因素是食用生肉或未煮熟的肉和较低的教育程度。这项研究提供了有关诊断为精神分裂症的罗马尼亚患者弓形虫病潜在危险因素的第一批数据，并可能为将来的研究和预防策略的制定奠定基础。
