METHODS: This retrospective cohort study analyzed data from the medical records of patients with T1D diagnosed between 15 and 40 years. Partial CR was defined as an IDAA1c index < 9. Patients in the intervention group received an infusion of adipose tissued-derived mesenchymal stem cells (ASCs) within 3 months after diagnosis and supplementation with 2000 IU of cholecalciferol for 1 year, started on the day following the infusion. Partial CR was also determined using the ISPAD criteria, to assess its agreement with IDAA1c.
RESULTS: A total of 28 patients were evaluated: 7 in the intervention group (group 1) and 21 in the control group (group 2). All patients in group 1 evolved with partial CR while only 46.7% of patients in group 2 had this outcome. Group 1 had a higher frequency of CR when evaluated with IDAA1c and ISPAD criteria. The mean duration of CR varied between the two criteria. Although HbA1c was similar between groups during follow-up, group 1 had a lower total daily insulin requirement (p < 0.005) at all time points. At 36 months, group 1 used 49% of the total daily insulin dose used by group 2 with similar glycemic control.
CONCLUSIONS: The intervention with infusion of ASC + vitamin D supplementation was associated with partial CR at 6 months. Although there were no differences in CR established by the IDAA1c and ISPAD criteria after three years of follow-up, patients who underwent intervention had nearly the half insulin requirement of controls with conventional treatment, with similar glycemic control.
BACKGROUND: 37001514.0.0000.5257.
方法:这项回顾性队列研究分析了诊断为15至40岁的T1D患者的病历数据。部分CR定义为IDA1c指数<9。干预组患者在诊断后3个月内接受脂肪组织间充质干细胞(ASCs)输注,并补充2000IU胆钙化醇1年,从输液后的第二天开始。部分CR也使用ISPAD标准确定,评估其与IDAA1c的协议。
结果:共评估了28例患者:干预组(第1组)7例,对照组(第2组)21例。第1组的所有患者均出现部分CR,而第2组只有46.7%的患者出现这种结果。当用IDAA1c和ISPAD标准评估时,第1组的CR频率更高。CR的平均持续时间在两个标准之间变化。虽然HbA1c在随访期间组间相似,在所有时间点,第1组的每日胰岛素总需求量较低(p<0.005).36个月时,第1组使用了第2组每日胰岛素总剂量的49%,血糖控制相似.
结论:在6个月时,输注ASC+维生素D的干预与部分CR相关。尽管经过三年的随访,IDAA1c和ISPAD标准确定的CR没有差异,接受干预的患者胰岛素需求量接近常规治疗对照组的一半,血糖控制相似。
背景:37001514.0.0000.5257。