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Abstract：
BACKGROUND: The incidence of neuroendocrine neoplasms (NENs) is rising rapidly worldwide. However, there are few reports on these heterogeneous diseases in China. Our study aimed to explore the epidemiological characteristics of NENs in Beijing.
METHODS: We conducted a retrospective cohort study using population-based cancer surveillance data in Beijing, China. All data were extracted from the Beijing Cancer Registry with incidence dates from 1 January 1998 to 31 December 2018; the follow-up period was through 31 December 2021. Segi\'s world standard population was used to estimate the age-standardized rate. Survival was estimated using the Kaplan-Meier method.
RESULTS: From 1998 to 2018, the incidence of NENs in Beijing initially showed a significant increasing trend, from 1.07/100,000 to 3.53/100,000; this began to plateau after 2013. The age-specific incidence rate increased with age and peaked in the age group 70-74 years. The incidence in men was significantly higher than that in women (4.41/100,000 vs. 1.69/100,000). The most common sites of NENs were the lung (2.38/100,000) and rectum (0.14/100,000). Most NENs were diagnosed at a late stage. We found that NENs originating from the lung had worse overall survival than extrapulmonary NENs, and male patients had worse survival than female patients.
CONCLUSIONS: This study retrospectively analyzed the epidemiological characteristics of NENs in Beijing from 1998 to 2018. Our findings provide a reference regarding the epidemiological statistics of NENs in Beijing to contribute to the prevention, diagnosis, and treatment of these specific tumors.
METHODS: We conducted a retrospective cohort study using population-based cancer surveillance data in Beijing, China. All data were extracted from the Beijing Cancer Registry with incidence dates from 1 January 1998 to 31 December 2018; the follow-up period was through 31 December 2021. Segi\'s world standard population was used to estimate the age-standardized rate. Survival was estimated using the Kaplan-Meier method.
RESULTS: From 1998 to 2018, the incidence of NENs in Beijing initially showed a significant increasing trend, from 1.07/100,000 to 3.53/100,000; this began to plateau after 2013. The age-specific incidence rate increased with age and peaked in the age group 70-74 years. The incidence in men was significantly higher than that in women (4.41/100,000 vs. 1.69/100,000). The most common sites of NENs were the lung (2.38/100,000) and rectum (0.14/100,000). Most NENs were diagnosed at a late stage. We found that NENs originating from the lung had worse overall survival than extrapulmonary NENs, and male patients had worse survival than female patients.
CONCLUSIONS: This study retrospectively analyzed the epidemiological characteristics of NENs in Beijing from 1998 to 2018. Our findings provide a reference regarding the epidemiological statistics of NENs in Beijing to contribute to the prevention, diagnosis, and treatment of these specific tumors.
摘要：
背景：神经内分泌肿瘤（NENs）的发病率在全球范围内迅速上升。然而,在中国很少有关于这些异质性疾病的报道。本研究旨在探讨北京地区NENs的流行病学特征。
方法：我们在北京使用基于人群的癌症监测数据进行了一项回顾性队列研究，中国。所有数据均来自北京肿瘤登记中心，发病日期为1998年1月1日至2018年12月31日；随访期至2021年12月31日。Segi的世界标准人口用于估计年龄标准化率。使用Kaplan-Meier方法估计存活率。
结果：从1998年到2018年，北京的NENs发病率初步呈明显上升趋势，从1.07/100,000到3.53/100,000；这在2013年之后开始趋于平稳。年龄特异性发病率随着年龄的增长而增加，并在70-74岁年龄组达到峰值。男性发病率明显高于女性(4.41/100,000vs.1.69/100,000）。NEN最常见的部位是肺(2.38/100,000)和直肠(0.14/100,000)。大多数NENs在晚期被诊断。我们发现源自肺的NENs比肺外的NENs有更差的总体生存率，男性患者的生存率比女性患者差。
结论：本研究回顾性分析了1998-2018年北京地区NENs的流行病学特征。我们的研究结果为北京NENs的流行病学统计提供了参考，有助于预防，诊断,和治疗这些特定的肿瘤。
方法：我们在北京使用基于人群的癌症监测数据进行了一项回顾性队列研究，中国。所有数据均来自北京肿瘤登记中心，发病日期为1998年1月1日至2018年12月31日；随访期至2021年12月31日。Segi的世界标准人口用于估计年龄标准化率。使用Kaplan-Meier方法估计存活率。
结果：从1998年到2018年，北京的NENs发病率初步呈明显上升趋势，从1.07/100,000到3.53/100,000；这在2013年之后开始趋于平稳。年龄特异性发病率随着年龄的增长而增加，并在70-74岁年龄组达到峰值。男性发病率明显高于女性(4.41/100,000vs.1.69/100,000）。NEN最常见的部位是肺(2.38/100,000)和直肠(0.14/100,000)。大多数NENs在晚期被诊断。我们发现源自肺的NENs比肺外的NENs有更差的总体生存率，男性患者的生存率比女性患者差。
结论：本研究回顾性分析了1998-2018年北京地区NENs的流行病学特征。我们的研究结果为北京NENs的流行病学统计提供了参考，有助于预防，诊断,和治疗这些特定的肿瘤。
