Abstract：
BACKGROUND: Androgenetic alopecia (AGA) is a prevalent type of hair loss that impacts individuals of both genders. Platelet-rich plasma (PRP) and minoxidil have been employed as therapeutic interventions for AGA, yet the efficacy of their concurrent use remains ambiguous.
OBJECTIVE: To perform a comprehensive review and meta-analysis aimed at evaluating the effectiveness of platelet-rich plasma (PRP) in combination with minoxidil for the treatment of androgenetic alopecia (AGA).
METHODS: We conducted a comprehensive search of the databases PubMed, Embase, Web of Science, and Cochrane Library, encompassing their complete records up until December 2023. Eligible studies were randomized controlled trials that compared the combination of PRP and minoxidil with minoxidil or PRP alone in patients with AGA. The primary outcome measure was the change in hair growth as assessed by the hair density or hair thickness. Secondary outcome measures included patient satisfaction, and global photographic assessment.
RESULTS: A total of 6 studies involving 343 participants were included in this meta-analysis. The results showed that PRP combined with minoxidil significantly improved hair growth compared to minoxidil or PRP alone. The pooled analysis demonstrated a significant increase in hair density (weighted mean difference [WMD] = 9.14; 95% confidence interval [CI]: 6.57-11.70) and hair diameter (WMD = 4.72; 95% CI 3.21-6.23) in the PRP combined with minoxidil group. Moreover, patients receiving PRP combined with minoxidil reported higher satisfaction rates compared to those using minoxidil or PRP alone.
CONCLUSIONS: This meta-analysis suggests that PRP combined with minoxidil is an effective treatment for AGA, providing significant improvement in hair growth and patient satisfaction.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
OBJECTIVE: To perform a comprehensive review and meta-analysis aimed at evaluating the effectiveness of platelet-rich plasma (PRP) in combination with minoxidil for the treatment of androgenetic alopecia (AGA).
METHODS: We conducted a comprehensive search of the databases PubMed, Embase, Web of Science, and Cochrane Library, encompassing their complete records up until December 2023. Eligible studies were randomized controlled trials that compared the combination of PRP and minoxidil with minoxidil or PRP alone in patients with AGA. The primary outcome measure was the change in hair growth as assessed by the hair density or hair thickness. Secondary outcome measures included patient satisfaction, and global photographic assessment.
RESULTS: A total of 6 studies involving 343 participants were included in this meta-analysis. The results showed that PRP combined with minoxidil significantly improved hair growth compared to minoxidil or PRP alone. The pooled analysis demonstrated a significant increase in hair density (weighted mean difference [WMD] = 9.14; 95% confidence interval [CI]: 6.57-11.70) and hair diameter (WMD = 4.72; 95% CI 3.21-6.23) in the PRP combined with minoxidil group. Moreover, patients receiving PRP combined with minoxidil reported higher satisfaction rates compared to those using minoxidil or PRP alone.
CONCLUSIONS: This meta-analysis suggests that PRP combined with minoxidil is an effective treatment for AGA, providing significant improvement in hair growth and patient satisfaction.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
摘要：
背景：雄激素性脱发（AGA）是一种普遍的脱发类型，会影响两种性别的个体。富血小板血浆（PRP）和米诺地尔已被用作AGA的治疗干预措施，然而，它们同时使用的功效仍然不明确。
目的：进行全面回顾和荟萃分析，旨在评估富血小板血浆（PRP）联合米诺地尔治疗雄激素性脱发（AGA）的有效性。
方法：我们对PubMed数据库进行了全面搜索，Embase,WebofScience,和Cochrane图书馆,包括他们直到2023年12月的完整记录。合格的研究是随机对照试验，比较了PRP和米诺地尔与米诺地尔或PRP单独在AGA患者中的组合。主要结果测量是通过毛发密度或毛发厚度评估的毛发生长的变化。次要结果指标包括患者满意度，和全球摄影评估。
结果：本荟萃分析共纳入6项研究，涉及343名参与者。结果显示,与单独的米诺地尔或PRP相比,与米诺地尔组合的PRP显著改善毛发生长。汇总分析表明，PRP联合米诺地尔组的头发密度（加权平均差[WMD]=9.14；95％置信区间[CI]：6.57-11.70）和头发直径（WMD=4.72；95％CI3.21-6.23）显着增加。此外，与单独使用米诺地尔或PRP的患者相比,接受PRP联合米诺地尔的患者报告的满意率更高.
结论：这项荟萃分析表明，PRP联合米诺地尔是治疗AGA的有效方法，提供头发生长和患者满意度的显着改善。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
目的：进行全面回顾和荟萃分析，旨在评估富血小板血浆（PRP）联合米诺地尔治疗雄激素性脱发（AGA）的有效性。
方法：我们对PubMed数据库进行了全面搜索，Embase,WebofScience,和Cochrane图书馆,包括他们直到2023年12月的完整记录。合格的研究是随机对照试验，比较了PRP和米诺地尔与米诺地尔或PRP单独在AGA患者中的组合。主要结果测量是通过毛发密度或毛发厚度评估的毛发生长的变化。次要结果指标包括患者满意度，和全球摄影评估。
结果：本荟萃分析共纳入6项研究，涉及343名参与者。结果显示,与单独的米诺地尔或PRP相比,与米诺地尔组合的PRP显著改善毛发生长。汇总分析表明，PRP联合米诺地尔组的头发密度（加权平均差[WMD]=9.14；95％置信区间[CI]：6.57-11.70）和头发直径（WMD=4.72；95％CI3.21-6.23）显着增加。此外，与单独使用米诺地尔或PRP的患者相比,接受PRP联合米诺地尔的患者报告的满意率更高.
结论：这项荟萃分析表明，PRP联合米诺地尔是治疗AGA的有效方法，提供头发生长和患者满意度的显着改善。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
