Abstract：
Epidemiological evidence indicates that exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with certain metabolic diseases. However, the relationship between PAHs and serum lipid profiles in exposed subjects remain unknown. Herein, the associations of multiple (8) urinary hydroxylated PAHs (OH-PAHs) in workers of coking (n = 655) and non-ferrous smelting (n = 614) industries with serum lipid levels (marking lipid metabolism) were examined. Multivariable linear regression, Bayesian kernel machine regression, and quantile g-computation were used. Most urinary OH-PAHs were significantly higher (p < 0.001) in coking workers than in non-ferrous smelting workers. In workers of both industries, OH-PAH exposure was associated with elevated levels of serum total cholesterol, total triglyceride, and low-density lipoprotein, as well as reduced high-density lipoprotein levels. Specifically, urinary 4-hydroxyphenanthrene was significantly positively associated with serum total cholesterol, total triglyceride, and low-density lipoprotein levels in non-ferrous smelting workers; however, the completely opposite association of 4-hydroxyphenanthrene with these lipid levels was observed in coking workers. The results of this pioneering examination suggest that exposure to OH-PAHs may contribute to dyslipidemia in coking and non-ferrous smelting workers, and distinct patterns of change were observed. Further prospective studies involving larger sample sizes are needed to further validate the findings.
摘要：
流行病学证据表明，接触多环芳烃（PAHs）与某些代谢性疾病有关。然而,暴露受试者中PAHs与血脂谱之间的关系尚不清楚.在这里，研究了焦化行业(n=655)和有色冶炼行业(n=614)工人中多种(8种)尿羟基化PAHs(OH-PAHs)与血脂水平(标记脂质代谢)的相关性.多变量线性回归，贝叶斯核机回归，并使用分位数g计算。炼焦工人的大多数尿OH-PAHs明显高于有色冶炼工人（p<0.001）。在这两个行业的工人中，OH-PAH暴露与血清总胆固醇水平升高有关，总甘油三酯，和低密度脂蛋白,以及降低高密度脂蛋白水平。具体来说,尿4-羟基菲与血清总胆固醇呈显著正相关,总甘油三酯，有色冶炼工人的低密度脂蛋白水平；然而，在焦化工人中观察到4-羟基菲与这些脂质水平完全相反的关联。这项开创性检查的结果表明，暴露于OH-PAHs可能会导致焦化和有色冶炼工人的血脂异常，并观察到不同的变化模式。需要涉及更大样本量的进一步前瞻性研究来进一步验证研究结果。
