关键词: AUC Acute kidney injury Loading dose Target attainment Vancomycin

Mesh : Vancomycin / administration & dosage pharmacokinetics Humans Retrospective Studies Anti-Bacterial Agents / administration & dosage pharmacokinetics Male Female Middle Aged Area Under Curve Aged Adult

来  源:   DOI:10.1016/j.diagmicrobio.2024.116355

Abstract:
This retrospective chart review evaluated whether 20 mg/kg vancomycin loading doses increase early area under the curve (AUC) target attainment within 48 hours in comparison to non-loading dose regimens. There were no differences between groups for the primary outcome (46 % vs. 50 %; P = 0.58).
摘要:
该回顾性图表评估了与非负荷剂量方案相比,20mg/kg万古霉素负荷剂量是否在48小时内增加了曲线下早期面积(AUC)目标实现。两组之间的主要结局没有差异(46%vs.50%;P=0.58)。
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