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Abstract：
The burgeoning field of metabolomics has piqued the interest of researchers in the context of benign gallbladder diseases, which include conditions such as gallbladder polyps, gallstones, and cholecystitis, which are common digestive system disorders. As metabolomics continues to advance, researchers have increasingly focused their attention on its applicability in the study of benign gallbladder diseases to provide new perspectives for diagnostic, therapeutic, and prognostic evaluation. This comprehensive review primarily describes the techniques of liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, and nuclear magnetic resonance and their respective applications in the study of benign gallbladder disease. Metabolomics has made remarkable progress in various aspects of these diseases, ranging from early diagnosis, etiological research, assessment of disease progression and prognosis, and optimization of therapeutic strategies. However, challenges remain in the field of metabolomics in the study of benign gallbladder diseases. These include issues related to data processing and analysis, biomarker discovery and validation, interdisciplinary research integration, and the advancement of personalized medicine. This article attempts to summarize research findings to date, highlight future research directions, and provide a reference point for metabolomics research in benign gallbladder disease.
摘要：
代谢组学的新兴领域引起了研究人员对良性胆囊疾病的兴趣，其中包括胆囊息肉等病症，胆结石,和胆囊炎,这是常见的消化系统疾病。随着代谢组学的不断进步，研究人员越来越关注其在良性胆囊疾病研究中的适用性，为诊断提供新的视角，治疗性的,和预后评估。这篇全面的综述主要描述了液相色谱-质谱联用技术，气相色谱-质谱,和核磁共振及其在良性胆囊疾病研究中的应用。代谢组学在这些疾病的各个方面都取得了显著的进展,从早期诊断开始，病因学研究，评估疾病进展和预后，和优化治疗策略。然而,代谢组学在良性胆囊疾病的研究中仍然存在挑战。其中包括与数据处理和分析有关的问题，生物标志物发现和验证，跨学科研究整合，以及个性化医疗的发展。本文试图总结迄今为止的研究成果，突出未来的研究方向，为良性胆囊疾病的代谢组学研究提供参考。
