UNASSIGNED: Using national public health databases, we identified children hospitalized between 2015 and 2022 with PAIS. Using an age proxy (29 days to 7 years) and excluding patients with cardiac and hematologic conditions, we focused on children with PAIS presumably related to focal cerebral arteriopathy or with no definite cause. Considering the delay between infection and PAIS occurrence, we compared a prepandemic reference period, a period with nonpharmaceutical interventions, and a post-nonpharmaceutical intervention period.
UNASSIGNED: Interrupted time-series analyses of the monthly incidence of PAIS in this group showed a significant decrease in the nonpharmaceutical intervention period compared with the prepandemic period: -33.5% (95% CI, -55.2%, -1.3%); P=0.043.
UNASSIGNED: These data support the association between infection and PAIS presumably related to focal cerebral arteriopathy.
■使用国家公共卫生数据库,我们确定了2015年至2022年间接受PAIS治疗的儿童.使用年龄指标(29天至7岁)并排除患有心脏和血液学疾病的患者,我们关注的是可能与局灶性脑动脉病相关或无明确病因的PAIS患儿.考虑到感染和PAIS发生之间的延迟,我们比较了一个流行病的参考期,非药物干预的时期,和非药物干预后的时期。
■对该组中PAIS每月发生率的中断时间序列分析显示,与流行前期相比,非药物干预期显着降低:-33.5%(95%CI,-55.2%,-1.3%);P=0.043。
■这些数据支持感染与可能与局灶性脑动脉病相关的PAIS之间的关联。