关键词: COVID-19 child incidence ischemic stroke public health

Mesh : Humans COVID-19 / epidemiology complications Ischemic Stroke / epidemiology Child Child, Preschool Infant Male Female Incidence Infant, Newborn SARS-CoV-2 Pandemics Cerebral Arterial Diseases / epidemiology Adolescent Interrupted Time Series Analysis

来  源:   DOI:10.1161/STROKEAHA.123.045632

Abstract:
UNASSIGNED: Infection may trigger pediatric arterial ischemic stroke (PAIS), notably when related to focal cerebral arteriopathy. Community- and individual-level nonpharmaceutical interventions during the COVID-19 pandemic resulted in a major decrease in pediatric viral infections. We explored the consequences on the incidence of PAIS.
UNASSIGNED: Using national public health databases, we identified children hospitalized between 2015 and 2022 with PAIS. Using an age proxy (29 days to 7 years) and excluding patients with cardiac and hematologic conditions, we focused on children with PAIS presumably related to focal cerebral arteriopathy or with no definite cause. Considering the delay between infection and PAIS occurrence, we compared a prepandemic reference period, a period with nonpharmaceutical interventions, and a post-nonpharmaceutical intervention period.
UNASSIGNED: Interrupted time-series analyses of the monthly incidence of PAIS in this group showed a significant decrease in the nonpharmaceutical intervention period compared with the prepandemic period: -33.5% (95% CI, -55.2%, -1.3%); P=0.043.
UNASSIGNED: These data support the association between infection and PAIS presumably related to focal cerebral arteriopathy.
摘要:
感染可能引发小儿动脉缺血性卒中(PAIS),特别是当与局灶性脑动脉病有关时。在COVID-19大流行期间,社区和个人层面的非药物干预导致儿科病毒感染大幅减少。我们探讨了对PAIS发病率的影响。
使用国家公共卫生数据库,我们确定了2015年至2022年间接受PAIS治疗的儿童.使用年龄指标(29天至7岁)并排除患有心脏和血液学疾病的患者,我们关注的是可能与局灶性脑动脉病相关或无明确病因的PAIS患儿.考虑到感染和PAIS发生之间的延迟,我们比较了一个流行病的参考期,非药物干预的时期,和非药物干预后的时期。
对该组中PAIS每月发生率的中断时间序列分析显示,与流行前期相比,非药物干预期显着降低:-33.5%(95%CI,-55.2%,-1.3%);P=0.043。
这些数据支持感染与可能与局灶性脑动脉病相关的PAIS之间的关联。
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