Abstract：
The disease severity of psoriasis is mainly assessed subjectively via psoriasis area and severity index (PASI) and body surface area (BSA), while an optimal measure of cutaneous response, may overlook systemic inflammation in psoriasis patients. The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), monocyte to high density lipoprotein ratio (MHR), and systemic immune-inflammation index (SII) exhibit notable associations with the inflammation severity in multiple diseases. The aim of this retrospective study was to explore the associations between inflammatory parameters and the skin lesions\' severity of psoriasis. After analysis, we found that patients with psoriasis had higher NLR, MLR, PLR, MHR, and SII levels compared to the control group. At baseline, the parameters of NLR (r = 0.124, P = 0.003), MLR (r = 0.153, P < 0.001), MHR (r = 0.217, P < 0.001) and SII (r = 0.141, P = 0.001) had a positive correlation with PASI in psoriasis patients. At the same time, we analyzed the patients who received different systemic therapy. We observed a significant decrease in NLR, PLR, MLR, and SII in psoriasis patients after treatment. Notably, TNF-α inhibitors and IL-17A inhibitors subgroups showed a more significant reduction than IL-23/IL-12/23 inhibitors and MTX medication. Additionally, we found the change of NLR (r = 0.194, P < 0.001), PLR (r = 0.104, P = 0.014), MLR (r = 0.191, P < 0.001), MHR (r = 0.106, P = 0.012), and SII (r = 0.228, P < 0.001) had a positive correlation with the change of PASI in psoriasis patients. In conclusion, this study suggests that NLR, MLR, and SII may serve as useful biomarkers for assessing systemic inflammation extent and disease severity in psoriasis patients.
摘要：
银屑病的严重程度主要通过银屑病面积和严重程度指数(PASI)和体表面积(BSA)进行主观评估,虽然是皮肤反应的最佳量度，可能忽略银屑病患者的全身性炎症。中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR），单核细胞与淋巴细胞比率（MLR），单核细胞与高密度脂蛋白比（MHR），全身免疫炎症指数（SII）与多种疾病的炎症严重程度显着相关。这项回顾性研究的目的是探讨炎症参数与银屑病皮损严重程度之间的关系。经过分析,我们发现银屑病患者的NLR较高，MLR,PLR,MHR,和SII水平与对照组相比。在基线,NLR的参数(r=0.124，P=0.003)，MLR(r=0.153,P<0.001),银屑病患者的MHR(r=0.217,P<0.001)和SII(r=0.141,P=0.001)与PASI呈正相关。同时,我们分析了接受不同系统治疗的患者.我们观察到NLR显著下降，PLR,MLR,和SII在银屑病患者治疗后。值得注意的是,TNF-α抑制剂和IL-17A抑制剂亚组显示比IL-23/IL-12/23抑制剂和MTX药物更显著的降低。此外,我们发现NLR的变化(r=0.194，P<0.001)，PLR(r=0.104,P=0.014),MLR(r=0.191,P<0.001),MHR(r=0.106,P=0.012),SII与银屑病患者PASI的改变呈正相关(r=0.228,P<0.001)。总之,这项研究表明，NLR，MLR,SII和SII可作为评估银屑病患者全身炎症程度和疾病严重程度的有用生物标志物。
