PDF(Pubmed)
Abstract：
A common infection, human cytomegalovirus (HCMV) has been associated with a variety of human diseases, including cardiovascular disease and possibly certain cancers. HCMV has also been associated with cognitive, psychiatric, and neurological conditions. Children with congenital or early-life HCMV are at risk for microcephaly, cerebral palsy, and sensorineural hearing loss, although in many cases sensorineural loss may resolve. In addition, HCMV can be associated with neurodevelopmental impairment, which may improve with time. In young, middle-aged, and older adults, HCMV has been adversely associated with cognitive function in some but not in all studies. Research has linked HCMV to Alzheimer\'s and vascular dementia, but again not all findings consistently support these associations. In addition, HCMV has been associated with depressive disorder, bipolar disorder, anxiety, and autism-spectrum disorder, although the available findings are likewise inconsistent. Given associations between HCMV and a variety of neurocognitive and neuropsychiatric disorders, additional research investigating reasons for the considerable inconsistencies in the currently available findings is needed. Additional meta-analyses and more longitudinal studies are needed as well. Research into the effects of antiviral medication on cognitive and neurological outcomes and continued efforts in vaccine development have potential to lower the neurocognitive, neuropsychiatric, and neurological burden of HCMV infection.
摘要：
一种常见的感染，人巨细胞病毒(HCMV)与多种人类疾病,包括心血管疾病和可能的某些癌症。HCMV也与认知有关，精神病学,和神经疾病。患有先天性或早期HCMV的儿童有小头畸形的风险，脑瘫,和感觉神经性听力损失，尽管在许多情况下，感觉神经性丧失可能会解决。此外,HCMV可能与神经发育障碍有关，这可能会随着时间的推移而改善。在年轻的时候，中年,和老年人，在一些但并非所有研究中，HCMV与认知功能存在不利关系。研究已经将HCMV与阿尔茨海默氏症和血管性痴呆联系起来,但同样,并非所有研究结果都一致支持这些关联.此外,HCMV与抑郁症有关，双相情感障碍,焦虑,和自闭症谱系障碍，尽管现有的研究结果同样不一致。鉴于HCMV与各种神经认知和神经精神障碍之间的关联，需要进行更多的研究,以调查当前现有研究结果中相当不一致的原因.还需要更多的荟萃分析和更多的纵向研究。研究抗病毒药物对认知和神经结果的影响以及疫苗开发的持续努力有可能降低神经认知，神经精神病学，和HCMV感染的神经负担。
