PDF(Pubmed)
Abstract：
Insects, renowned for their abundant and renewable biomass, stand at the forefront of biomimicry-inspired research and offer promising alternatives for chitin and chitosan production considering mounting environmental concerns and the inherent limitations of conventional sources. This comprehensive review provides a meticulous exploration of the current state of insect-derived chitin and chitosan, focusing on their sources, production methods, characterization, physical and chemical properties, and emerging biomedical applications. Abundant insect sources of chitin and chitosan, from the Lepidoptera, Coleoptera, Orthoptera, Hymenoptera, Diptera, Hemiptera, Dictyoptera, Odonata, and Ephemeroptera orders, were comprehensively summarized. A variety of characterization techniques, including spectroscopy, chromatography, and microscopy, were used to reveal their physical and chemical properties like molecular weight, degree of deacetylation, and crystallinity, laying a solid foundation for their wide application, especially for the biomimetic design process. The examination of insect-derived chitin and chitosan extends into a wide realm of biomedical applications, highlighting their unique advantages in wound healing, tissue engineering, drug delivery, and antimicrobial therapies. Their intrinsic biocompatibility and antimicrobial properties position them as promising candidates for innovative solutions in diverse medical interventions.
摘要：
昆虫,以其丰富和可再生的生物质而闻名，站在仿生研究的最前沿，并考虑到日益增加的环境问题和传统来源的固有局限性，为几丁质和壳聚糖生产提供有希望的替代品。这篇全面的综述对昆虫源性甲壳素和壳聚糖的现状进行了细致的探索，专注于他们的来源，生产方法,表征，物理和化学性质，和新兴的生物医学应用。甲壳素和壳聚糖的昆虫来源丰富，来自鳞翅目,鞘翅目,直翅目,膜翅目,双翅目,半翅目,网翅目,Odonata,和星翅目，进行了全面的总结。各种表征技术，包括光谱学，色谱，和显微镜,用来揭示它们的物理和化学性质，如分子量，脱乙酰度，和结晶度，为其广泛应用奠定坚实的基础，尤其是仿生设计过程。昆虫来源的几丁质和壳聚糖的检查扩展到生物医学应用的广泛领域，突出其在伤口愈合方面的独特优势，组织工程,药物输送,和抗菌治疗。它们固有的生物相容性和抗菌性能使它们成为各种医疗干预措施中创新解决方案的有希望的候选人。
