PDF(Pubmed)
Abstract：
BACKGROUND: Although coronary artery nomograms in children have been published, data on Caucasian children are lacking. The aim of this study is to provide: (i) a full dataset of coronary artery diameters in healthy children and (ii) a comparison among major previous nomograms.
METHODS: We prospectively evaluated 606 healthy subjects (age range, 1 days-<18 years; median age 8.7 years; 62.5% male). Coronary artery measurements in a short-axis view were performed. Age, heart rate, and body surface area (BSA) were used as independent variables in different analyses to predict the mean values of each measurement. To assess the accuracy of the predictive models of different studies, a Z-score calculator was created using Lopez\'s nomograms for comparison.
RESULTS: The association with BSA was found to be stronger, and was used for normalization of our data. The best-fit models, satisfying the assumption of homoscedasticity and normality of residuals and showing the highest R2 scores, were logarithmic (ln[y] = a + b*ln[x]). Predicted values and Z-score boundaries by BSA are provided. Our ranges of normality are slightly lower than those, diverging from -0.22 to -0.59 Z-scores for the left main coronary artery and from -0.23 to -0.3 Z-scores for the right coronary artery.
CONCLUSIONS: We report a complete dataset of normal echocardiography coronary artery diameter (including new measures of the proximal origin) values in a large population of healthy children. Our data were statistically like those of north American nomograms.
METHODS: We prospectively evaluated 606 healthy subjects (age range, 1 days-<18 years; median age 8.7 years; 62.5% male). Coronary artery measurements in a short-axis view were performed. Age, heart rate, and body surface area (BSA) were used as independent variables in different analyses to predict the mean values of each measurement. To assess the accuracy of the predictive models of different studies, a Z-score calculator was created using Lopez\'s nomograms for comparison.
RESULTS: The association with BSA was found to be stronger, and was used for normalization of our data. The best-fit models, satisfying the assumption of homoscedasticity and normality of residuals and showing the highest R2 scores, were logarithmic (ln[y] = a + b*ln[x]). Predicted values and Z-score boundaries by BSA are provided. Our ranges of normality are slightly lower than those, diverging from -0.22 to -0.59 Z-scores for the left main coronary artery and from -0.23 to -0.3 Z-scores for the right coronary artery.
CONCLUSIONS: We report a complete dataset of normal echocardiography coronary artery diameter (including new measures of the proximal origin) values in a large population of healthy children. Our data were statistically like those of north American nomograms.
摘要：
背景：尽管已经发表了儿童冠状动脉列线图，缺乏高加索儿童的数据。这项研究的目的是提供：（i）健康儿童冠状动脉直径的完整数据集，以及（ii）先前主要列线图之间的比较。
方法：我们前瞻性评估了606名健康受试者(年龄范围，1天-<18岁；中位年龄8.7岁；62.5%男性）。在短轴视图中进行冠状动脉测量。年龄,心率,和体表面积（BSA）被用作不同分析中的独立变量，以预测每次测量的平均值。为了评估不同研究预测模型的准确性，使用洛佩兹的列线图创建Z分数计算器进行比较。
结果：发现与BSA的关联更强，并用于对我们的数据进行归一化。最适合的模型，满足残差的同方差和正态的假设，并显示最高的R2分数，是对数的(ln[y]=a+b*ln[x])。提供了BSA的预测值和Z分数边界。我们的正常性范围略低于那些，左主干冠状动脉的Z评分从-0.22到-0.59，右冠状动脉的Z评分从-0.23到-0.3。
结论：我们报告了大量健康儿童的正常超声心动图冠状动脉直径（包括近端起源的新测量）值的完整数据集。我们的数据在统计上与北美列线图相似。
方法：我们前瞻性评估了606名健康受试者(年龄范围，1天-<18岁；中位年龄8.7岁；62.5%男性）。在短轴视图中进行冠状动脉测量。年龄,心率,和体表面积（BSA）被用作不同分析中的独立变量，以预测每次测量的平均值。为了评估不同研究预测模型的准确性，使用洛佩兹的列线图创建Z分数计算器进行比较。
结果：发现与BSA的关联更强，并用于对我们的数据进行归一化。最适合的模型，满足残差的同方差和正态的假设，并显示最高的R2分数，是对数的(ln[y]=a+b*ln[x])。提供了BSA的预测值和Z分数边界。我们的正常性范围略低于那些，左主干冠状动脉的Z评分从-0.22到-0.59，右冠状动脉的Z评分从-0.23到-0.3。
结论：我们报告了大量健康儿童的正常超声心动图冠状动脉直径（包括近端起源的新测量）值的完整数据集。我们的数据在统计上与北美列线图相似。
