PDF(Pubmed)
Abstract：
The rise of DNA nanotechnology has driven the development of DNA-based molecular machines, which are capable of performing specific operations and tasks at the nanoscale. Benefitting from the programmability of DNA molecules and the predictability of DNA hybridization and strand displacement, DNA-based molecular machines can be designed with various structures and dynamic behaviors and have been implemented for wide applications in the field of biosensing due to their unique advantages. This review summarizes the reported controlling mechanisms of DNA-based molecular machines and introduces biosensing applications of DNA-based molecular machines in amplified detection, multiplex detection, real-time monitoring, spatial recognition detection, and single-molecule detection of biomarkers. The challenges and future directions of DNA-based molecular machines in biosensing are also discussed.
摘要：
DNA纳米技术的兴起推动了DNA分子机器的发展,能够在纳米尺度上执行特定的操作和任务。得益于DNA分子的可编程性以及DNA杂交和链置换的可预测性，基于DNA的分子机器可以设计为具有各种结构和动态行为，并且由于其独特的优势而在生物传感领域得到了广泛的应用。这篇综述总结了已报道的基于DNA的分子机器的控制机制，并介绍了基于DNA的分子机器在扩增检测中的生物传感应用。多重检测，实时监控,空间识别检测，和生物标志物的单分子检测。还讨论了基于DNA的分子机器在生物传感中的挑战和未来方向。
