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Abstract：
The aim of this study is to examine the outcomes of an accelerated fractionated irradiation for N0 glottic carcinoma.
In this retrospective analysis, 29 patients with N0 glottic carcinoma treated by radiation therapy were enrolled. Thirteen patients had T1a disease, six had T1b disease, and ten had T2 disease. A fractional dose of 2.1 Gy was administered to seven patients. The total doses were 65.1 and 67.2 Gy in four and three patients, respectively. A fractional dose of 2.25 Gy was administered to 22 patients. The total doses were 63 and 67.5 Gy in 21 patients and 1 patient with T2 disease, respectively. Additionally, 13 patients underwent the use of TS-1 (80-100 mg per day).
The median follow-up period was 33 months, and the 3-year local control rate was 95.6%. No patient had a lymph node or distant recurrence. As acute adverse events, grades 2 and 3 dermatitis were observed in 18 patients and 1 patient, and grades 2 and 3 mucositis were observed in 15 patients and 1 patient. As a late adverse event, one patient required tracheotomy because of laryngeal edema occurring.
Accelerated fractionated irradiation may be an option in the radiation therapy of N0 glottic carcinoma because of its ability to shorten the treatment time.
In this retrospective analysis, 29 patients with N0 glottic carcinoma treated by radiation therapy were enrolled. Thirteen patients had T1a disease, six had T1b disease, and ten had T2 disease. A fractional dose of 2.1 Gy was administered to seven patients. The total doses were 65.1 and 67.2 Gy in four and three patients, respectively. A fractional dose of 2.25 Gy was administered to 22 patients. The total doses were 63 and 67.5 Gy in 21 patients and 1 patient with T2 disease, respectively. Additionally, 13 patients underwent the use of TS-1 (80-100 mg per day).
The median follow-up period was 33 months, and the 3-year local control rate was 95.6%. No patient had a lymph node or distant recurrence. As acute adverse events, grades 2 and 3 dermatitis were observed in 18 patients and 1 patient, and grades 2 and 3 mucositis were observed in 15 patients and 1 patient. As a late adverse event, one patient required tracheotomy because of laryngeal edema occurring.
Accelerated fractionated irradiation may be an option in the radiation therapy of N0 glottic carcinoma because of its ability to shorten the treatment time.
摘要：
背景：本研究的目的是检查NO声门型喉癌的加速分割照射的结果。
方法：在本回顾性分析中，纳入29例接受放射治疗的N0声门癌患者。13名患者患有T1a疾病，六个人患有T1b疾病，十个人患有T2疾病。向7名患者施用2.1Gy的分数剂量。4例和3例患者的总剂量分别为65.1和67.2Gy，分别。对22名患者施用2.25Gy的分数剂量。21例患者和1例T2患者的总剂量分别为63和67.5Gy，分别。此外,13名患者接受了TS-1的使用（每天80-100mg）。
结果：中位随访期为33个月，3年局部控制率为95.6%。没有患者有淋巴结或远处复发。作为急性不良事件，在18例患者和1例患者中观察到2级和3级皮炎，在15例患者和1例患者中观察到2级和3级粘膜炎。作为晚期不良事件，1例患者因喉水肿需要气管切开术。
结论：加速分割照射可缩短NO声门型喉癌的治疗时间。
方法：在本回顾性分析中，纳入29例接受放射治疗的N0声门癌患者。13名患者患有T1a疾病，六个人患有T1b疾病，十个人患有T2疾病。向7名患者施用2.1Gy的分数剂量。4例和3例患者的总剂量分别为65.1和67.2Gy，分别。对22名患者施用2.25Gy的分数剂量。21例患者和1例T2患者的总剂量分别为63和67.5Gy，分别。此外,13名患者接受了TS-1的使用（每天80-100mg）。
结果：中位随访期为33个月，3年局部控制率为95.6%。没有患者有淋巴结或远处复发。作为急性不良事件，在18例患者和1例患者中观察到2级和3级皮炎，在15例患者和1例患者中观察到2级和3级粘膜炎。作为晚期不良事件，1例患者因喉水肿需要气管切开术。
结论：加速分割照射可缩短NO声门型喉癌的治疗时间。
