小分子 TrkB 配体改善雌性 Rett 综合征小鼠的树突棘表型和非典型行为。
关键词: BDNF Hippocampus LM22A-4 MeCP2 Pyramidal neuron
Mesh : Animals Rett Syndrome / pathology drug therapy Dendritic Spines / drug effects metabolism pathology Female Phenotype Receptor, trkB / metabolism Methyl-CpG-Binding Protein 2 / metabolism genetics Behavior, Animal / drug effects Ligands Pyramidal Cells / drug effects metabolism pathology Mice Brain-Derived Neurotrophic Factor / metabolism Hippocampus / pathology metabolism drug effects Heterozygote Mice, Inbred C57BL Disease Models, Animal Benzamides
来 源:
DOI:10.1242/dmm.050612
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