PDF(Pubmed)
Abstract：
UNASSIGNED: Celiac disease (CeD) is associated with several immune-mediated disorders, but it is unclear whether it is associated with eosinophilic esophagitis (EoE).
UNASSIGNED: We sought to examine the risk of EoE in patients with biopsy-verified CeD compared with matched controls and siblings.
UNASSIGNED: Using nationwide population-based histopathology data, we identified 27,338 patients with CeD diagnosed in the period 2002 to 2017 in Sweden. Patients with CeD were age- and sex-matched with up to 5 reference individuals (n = 134,987) from the general population. Cox Regression was used to estimate hazard ratios (HRs) for developing biopsy-verified EoE. In a secondary analysis, we used unaffected siblings of patients with CeD as comparators to adjust for intrafamilial confounding.
UNASSIGNED: The median age at CeD diagnosis was 27 years, and 63.3% were female patients. During a median follow-up of 8.1 years, 17 patients with CeD and 13 matched reference individuals were diagnosed with EoE. This corresponded to incidence rates of 0.08 versus 0.01 per 1000 person-years, respectively, and an adjusted HR for EoE of 6.65 (95% CI, 3.26-13.81). Compared with their siblings without CeD, patients with CeD were however at a no increased risk of EoE (HR, 1.39; 95% CI, 0.55-3.51).
UNASSIGNED: In this study, individuals with CeD were at a 6.6-fold increased risk of later EoE compared with the general population. This association might be explained by an altered health-seeking behavior or through shared genetic or early environmental factors because the excess risk disappeared in sibling analyses.
UNASSIGNED: We sought to examine the risk of EoE in patients with biopsy-verified CeD compared with matched controls and siblings.
UNASSIGNED: Using nationwide population-based histopathology data, we identified 27,338 patients with CeD diagnosed in the period 2002 to 2017 in Sweden. Patients with CeD were age- and sex-matched with up to 5 reference individuals (n = 134,987) from the general population. Cox Regression was used to estimate hazard ratios (HRs) for developing biopsy-verified EoE. In a secondary analysis, we used unaffected siblings of patients with CeD as comparators to adjust for intrafamilial confounding.
UNASSIGNED: The median age at CeD diagnosis was 27 years, and 63.3% were female patients. During a median follow-up of 8.1 years, 17 patients with CeD and 13 matched reference individuals were diagnosed with EoE. This corresponded to incidence rates of 0.08 versus 0.01 per 1000 person-years, respectively, and an adjusted HR for EoE of 6.65 (95% CI, 3.26-13.81). Compared with their siblings without CeD, patients with CeD were however at a no increased risk of EoE (HR, 1.39; 95% CI, 0.55-3.51).
UNASSIGNED: In this study, individuals with CeD were at a 6.6-fold increased risk of later EoE compared with the general population. This association might be explained by an altered health-seeking behavior or through shared genetic or early environmental factors because the excess risk disappeared in sibling analyses.
摘要：
■乳糜泻（CeD）与几种免疫介导的疾病有关，但尚不清楚它是否与嗜酸性粒细胞性食管炎（EoE）有关。
■我们试图检查活检证实的CeD患者与匹配的对照组和兄弟姐妹的EoE风险。
■使用全国人群的组织病理学数据，我们确定了2002年至2017年期间在瑞典诊断的27338例CeD患者.CeD患者的年龄和性别与一般人群中多达5名参考个体（n=134,987）相匹配。Cox回归用于评估开发活检验证的EoE的风险比（HRs）。在次要分析中，我们使用CeD患者未受影响的兄弟姐妹作为比较器来校正家族内混杂因素.
■诊断为CeD的中位年龄为27岁，63.3%为女性患者。在8.1年的中位随访期间，17名CeD患者和13名匹配的参考个体被诊断为EoE。这对应于每1000人年0.08和0.01的发病率，分别,EoE的校正HR为6.65（95%CI，3.26-13.81）。与没有CeD的兄弟姐妹相比，然而，CeD患者的EoE风险没有增加(HR，1.39；95%CI，0.55-3.51）。
■在这项研究中，与一般人群相比,CeD患者发生晚期EoE的风险增加6.6倍.这种关联可能是通过改变寻求健康的行为或通过共同的遗传或早期环境因素来解释的，因为在兄弟姐妹分析中，超额风险消失了。
■我们试图检查活检证实的CeD患者与匹配的对照组和兄弟姐妹的EoE风险。
■使用全国人群的组织病理学数据，我们确定了2002年至2017年期间在瑞典诊断的27338例CeD患者.CeD患者的年龄和性别与一般人群中多达5名参考个体（n=134,987）相匹配。Cox回归用于评估开发活检验证的EoE的风险比（HRs）。在次要分析中，我们使用CeD患者未受影响的兄弟姐妹作为比较器来校正家族内混杂因素.
■诊断为CeD的中位年龄为27岁，63.3%为女性患者。在8.1年的中位随访期间，17名CeD患者和13名匹配的参考个体被诊断为EoE。这对应于每1000人年0.08和0.01的发病率，分别,EoE的校正HR为6.65（95%CI，3.26-13.81）。与没有CeD的兄弟姐妹相比，然而，CeD患者的EoE风险没有增加(HR，1.39；95%CI，0.55-3.51）。
■在这项研究中，与一般人群相比,CeD患者发生晚期EoE的风险增加6.6倍.这种关联可能是通过改变寻求健康的行为或通过共同的遗传或早期环境因素来解释的，因为在兄弟姐妹分析中，超额风险消失了。
