{Reference Type}: Journal Article {Title}: Association of celiac disease with eosinophilic esophagitis: Nationwide register-based cohort study with sibling analyses. {Author}: Mitselou N;Uchida A;Roelstraete B;Melén E;Garber JJ;Katzka D;Lebwohl B;Green PHR;Ludvigsson JF; {Journal}: J Allergy Clin Immunol Glob {Volume}: 3 {Issue}: 3 {Year}: 2024 Aug 暂无{DOI}: 10.1016/j.jacig.2024.100254 {Abstract}: UNASSIGNED: Celiac disease (CeD) is associated with several immune-mediated disorders, but it is unclear whether it is associated with eosinophilic esophagitis (EoE).
UNASSIGNED: We sought to examine the risk of EoE in patients with biopsy-verified CeD compared with matched controls and siblings.
UNASSIGNED: Using nationwide population-based histopathology data, we identified 27,338 patients with CeD diagnosed in the period 2002 to 2017 in Sweden. Patients with CeD were age- and sex-matched with up to 5 reference individuals (n = 134,987) from the general population. Cox Regression was used to estimate hazard ratios (HRs) for developing biopsy-verified EoE. In a secondary analysis, we used unaffected siblings of patients with CeD as comparators to adjust for intrafamilial confounding.
UNASSIGNED: The median age at CeD diagnosis was 27 years, and 63.3% were female patients. During a median follow-up of 8.1 years, 17 patients with CeD and 13 matched reference individuals were diagnosed with EoE. This corresponded to incidence rates of 0.08 versus 0.01 per 1000 person-years, respectively, and an adjusted HR for EoE of 6.65 (95% CI, 3.26-13.81). Compared with their siblings without CeD, patients with CeD were however at a no increased risk of EoE (HR, 1.39; 95% CI, 0.55-3.51).
UNASSIGNED: In this study, individuals with CeD were at a 6.6-fold increased risk of later EoE compared with the general population. This association might be explained by an altered health-seeking behavior or through shared genetic or early environmental factors because the excess risk disappeared in sibling analyses.