PDF(Pubmed)
Abstract：
UNASSIGNED: Diffusion-weighted imaging (DWI) is the random Brownian motion of water molecules within a tissue voxel. The apparent diffusion coefficient (ADC) is a quantitative parameter calculated from the DWI that directly reflects the mobility of water molecules in biological tissues. The objective of this study was to establish and compare the normal reference ADC values of fetal organs and the placenta using 1.5 T and 3.0 T MRI at various gestational ages.
UNASSIGNED: This was a retrospective and prospective observational study. This study included one hundred and three (103) singleton pregnancies for each magnetic field strength. Diffusion-weighted imaging was performed using single-shot spin-echo-planar imaging (EPI) in the axial plane of the fetal head-trunk with a slice thickness of 4mm and diffusion gradient values of b = 0 and b = 700-800 s/mm2.
UNASSIGNED: The mean ADC values of cerebral WM areas were significantly higher than the deep grey areas in the brain. The white-matter regions, lung, and placenta showed a positive and significant correlation with increasing gestational age in both field strengths. A statistically weak negative correlation was observed between increasing gestational age and ADC measurements obtained in the thalamus, cerebellum, pons, and kidney.
UNASSIGNED: This study gives the reference values for both 1.5T and 3T MRI of vital organs. The current study shows that diffusion-weighted MRI can offer a promising technique to evaluate the structural development of fetal organs and can potentially act as a biomarker for predicting the functionality of the fetal organs in abnormalities.
UNASSIGNED: This was a retrospective and prospective observational study. This study included one hundred and three (103) singleton pregnancies for each magnetic field strength. Diffusion-weighted imaging was performed using single-shot spin-echo-planar imaging (EPI) in the axial plane of the fetal head-trunk with a slice thickness of 4mm and diffusion gradient values of b = 0 and b = 700-800 s/mm2.
UNASSIGNED: The mean ADC values of cerebral WM areas were significantly higher than the deep grey areas in the brain. The white-matter regions, lung, and placenta showed a positive and significant correlation with increasing gestational age in both field strengths. A statistically weak negative correlation was observed between increasing gestational age and ADC measurements obtained in the thalamus, cerebellum, pons, and kidney.
UNASSIGNED: This study gives the reference values for both 1.5T and 3T MRI of vital organs. The current study shows that diffusion-weighted MRI can offer a promising technique to evaluate the structural development of fetal organs and can potentially act as a biomarker for predicting the functionality of the fetal organs in abnormalities.
摘要：
■扩散加权成像（DWI）是组织体素内水分子的随机布朗运动。表观扩散系数（ADC）是根据DWI计算的定量参数，它直接反映了生物组织中水分子的迁移率。这项研究的目的是使用1.5T和3.0TMRI在不同胎龄下建立并比较胎儿器官和胎盘的正常参考ADC值。
■这是一项回顾性和前瞻性观察性研究。这项研究包括每个磁场强度的一百零三（103）个单胎妊娠。采用单次自旋回波平面成像(EPI)在胎头干轴面上进行弥散加权成像,切片厚度为4mm,弥散梯度值为b=0,b=700～800s/mm2。
■大脑WM区域的平均ADC值明显高于大脑中的深灰色区域。白质区域，肺，在两个场强中，胎盘与胎龄的增加均呈正相关且显着相关。在增加的胎龄和丘脑中获得的ADC测量值之间观察到统计学上的弱负相关，小脑,pons,还有肾.
■这项研究给出了重要器官1.5T和3TMRI的参考值。目前的研究表明，扩散加权MRI可以提供一种有前途的技术来评估胎儿器官的结构发育，并且可以作为预测异常中胎儿器官功能的生物标志物。
■这是一项回顾性和前瞻性观察性研究。这项研究包括每个磁场强度的一百零三（103）个单胎妊娠。采用单次自旋回波平面成像(EPI)在胎头干轴面上进行弥散加权成像,切片厚度为4mm,弥散梯度值为b=0,b=700～800s/mm2。
■大脑WM区域的平均ADC值明显高于大脑中的深灰色区域。白质区域，肺，在两个场强中，胎盘与胎龄的增加均呈正相关且显着相关。在增加的胎龄和丘脑中获得的ADC测量值之间观察到统计学上的弱负相关，小脑,pons,还有肾.
■这项研究给出了重要器官1.5T和3TMRI的参考值。目前的研究表明，扩散加权MRI可以提供一种有前途的技术来评估胎儿器官的结构发育，并且可以作为预测异常中胎儿器官功能的生物标志物。
