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Abstract：
BACKGROUND: With the development of pathophysiology, cardiorenal syndrome (CRS), a complex and severe disease, has received increasing attention. Monocyte to high-density lipoprotein-cholesterol ratio (MHR) and body mass index (BMI) are independent risk factors for cardiovascular diseases, but their association with CRS remains unexplored. This study aims to explore the independent and joint effects of MHR and BMI on CRS.
METHODS: We included 42,178 NHANES participants. The determination of CRS referred to the simultaneous presence of cardiovascular disease (identified through self-report) and chronic kidney disease (eGFR < 60 mL/min per 1.73 m²). We employed multivariate weighted logistic regression to evaluate the odds ratio (OR) and 95% confidence interval (CI) for the independent and joint associations of MHR and BMI with CRS. We also conducted restricted cubic spines to explore nonlinear associations.
RESULTS: The prevalence of CRS was 3.45% among all participants. An increase in both MHR and BMI is associated with a higher risk of CRS (MHR: OR = 1.799, 95% CI = 1.520-2.129, P < 0.001, P-trend < 0.001; BMI: OR = 1.037, 95% CI = 1.023-1.051, P < 0.001). Individuals who simultaneously fall into the highest quartile of MHR and have a BMI of 30 or more face the highest risk of CRS compared to those in the lowest MHR quartile with a BMI of less than 25 (OR = 3.45, 95% CI = 2.40-4.98, P < 0.001). However, there is no interactive association between MHR and BMI with CRS.
CONCLUSIONS: Higher MHR and BMI are associated with higher odds of CRS. MHR and BMI can serve as tools for early prevention and intervention of CRS, respectively.
METHODS: We included 42,178 NHANES participants. The determination of CRS referred to the simultaneous presence of cardiovascular disease (identified through self-report) and chronic kidney disease (eGFR < 60 mL/min per 1.73 m²). We employed multivariate weighted logistic regression to evaluate the odds ratio (OR) and 95% confidence interval (CI) for the independent and joint associations of MHR and BMI with CRS. We also conducted restricted cubic spines to explore nonlinear associations.
RESULTS: The prevalence of CRS was 3.45% among all participants. An increase in both MHR and BMI is associated with a higher risk of CRS (MHR: OR = 1.799, 95% CI = 1.520-2.129, P < 0.001, P-trend < 0.001; BMI: OR = 1.037, 95% CI = 1.023-1.051, P < 0.001). Individuals who simultaneously fall into the highest quartile of MHR and have a BMI of 30 or more face the highest risk of CRS compared to those in the lowest MHR quartile with a BMI of less than 25 (OR = 3.45, 95% CI = 2.40-4.98, P < 0.001). However, there is no interactive association between MHR and BMI with CRS.
CONCLUSIONS: Higher MHR and BMI are associated with higher odds of CRS. MHR and BMI can serve as tools for early prevention and intervention of CRS, respectively.
摘要：
背景：随着病理生理学的发展，心肾综合征(CRS),一种复杂而严重的疾病，受到越来越多的关注。单核细胞与高密度脂蛋白胆固醇比值(MHR)和体重指数(BMI)是心血管疾病的独立危险因素。但他们与CRS的联系仍未被探索。本研究旨在探讨MHR和BMI对CRS的独立和联合影响。
方法：我们包括42,178名NHANES参与者。CRS的确定是指同时存在心血管疾病（通过自我报告确定）和慢性肾脏疾病（eGFR<60mL/min/1.73m²）。我们采用多变量加权逻辑回归来评估MHR和BMI与CRS的独立和联合关联的比值比（OR）和95％置信区间（CI）。我们还进行了有限的立方棘，以探索非线性关联。
结果：所有参与者中CRS的患病率为3.45%。MHR和BMI的增加与CRS的高风险相关（MHR：OR=1.799，95％CI=1.520-2.129，P<0.001，P趋势<0.001；BMI：OR=1.037，95％CI=1.023-1.051，P<0.001）。与BMI小于25的最低MHR四分位数的人相比，同时处于MHR最高四分位数且BMI为30或更高的人面临CRS的风险最高（OR=3.45，95％CI=2.40-4.98，P<0.001）。然而,MHR和BMI与CRS之间没有交互关联。
结论：较高的MHR和BMI与较高的CRS几率相关。MHR和BMI可以作为早期预防和干预CRS的工具，分别。
方法：我们包括42,178名NHANES参与者。CRS的确定是指同时存在心血管疾病（通过自我报告确定）和慢性肾脏疾病（eGFR<60mL/min/1.73m²）。我们采用多变量加权逻辑回归来评估MHR和BMI与CRS的独立和联合关联的比值比（OR）和95％置信区间（CI）。我们还进行了有限的立方棘，以探索非线性关联。
结果：所有参与者中CRS的患病率为3.45%。MHR和BMI的增加与CRS的高风险相关（MHR：OR=1.799，95％CI=1.520-2.129，P<0.001，P趋势<0.001；BMI：OR=1.037，95％CI=1.023-1.051，P<0.001）。与BMI小于25的最低MHR四分位数的人相比，同时处于MHR最高四分位数且BMI为30或更高的人面临CRS的风险最高（OR=3.45，95％CI=2.40-4.98，P<0.001）。然而,MHR和BMI与CRS之间没有交互关联。
结论：较高的MHR和BMI与较高的CRS几率相关。MHR和BMI可以作为早期预防和干预CRS的工具，分别。
