UNASSIGNED: We prospectively collected blood samples from 149 patients and utilized inductively coupled plasma mass spectrometry to examine their venous serum trace element concentrations. Logistic regression analyses were used to investigate the association between Ca and malnutrition. Receiver operating characteristic (ROC) curves were generated to calculate the cutoffs for determination of Ca deficiency.
UNASSIGNED: Except Ca, the concentrations of the other six trace elements presented no statistical significance between non-malnutrition and malnutrition group. In comparison with the non-malnutrition group, the serum concentration of Ca decreased in the malnutrition group (89.36 vs 87.03 mg/L, p = 0.023). With regard to ROC curve, Ca < 87.21 mg/L showed the best discriminative capability with an area of 0.624 (95% CI: 0.520, 0.727, p = 0.023). Multivariate analyses demonstrated that Ca < 87.21 mg/L (OR = 3.393, 95% CI: 1.524, 7.554, p = 0.003) and age (OR = 0.958, 95% CI: 0.926, 0.990, p = 0.011) were associated with malnutrition risk. Serum Ca levels were significantly lower in the malnutrition group than those in the non-malnutrition group among UC patients, those with severe disease state or the female group.
UNASSIGNED: In patients with IBD, Ca deficiency is an independent factor for high malnutrition risk.
■我们前瞻性地收集了149名患者的血液样本,并利用电感耦合等离子体质谱法检查了他们的静脉血清微量元素浓度。采用Logistic回归分析研究钙与营养不良的关系。产生接收器工作特征(ROC)曲线以计算用于测定Ca缺乏的截止值。
■除了Ca,其他6种微量元素的浓度在非营养不良组和营养不良组之间无统计学意义.与非营养不良组相比,营养不良组血清钙浓度降低(89.36vs87.03mg/L,p=0.023)。关于ROC曲线,Ca<87.21mg/L显示最佳判别能力,面积为0.624(95%CI:0.520,0.727,p=0.023)。多因素分析显示,钙<87.21mg/L(OR=3.393,95%CI:1.524,7.554,p=0.003)和年龄(OR=0.958,95%CI:0.926,0.990,p=0.011)与营养不良风险相关。UC患者营养不良组血清Ca水平明显低于非营养不良组,患有严重疾病的人或女性群体。
■在IBD患者中,钙缺乏是高营养不良风险的独立因素。