Abstract：
OBJECTIVE: Does an association exist between neighbourhood socioeconomic status (SES) and the cumulative rate of ongoing pregnancies after 2.5 years of IVF treatment?
METHODS: A retrospective observational study involving 2669 couples who underwent IVF or IVF and intracytoplasmic sperm injection treatment between 2006 and 2020. Neighbourhood SES for each couple was determined based on their residential postal code. Subsequently, SES was categorized into low (p80). Multivariable binary logistic regression analyses were conducted, with the cumulative ongoing pregnancy within 2.5 years as the outcome variable. The SES category (reference category: high), female age (reference category: 32-36 years), body mass index (reference category: 23-25 kg/m2), smoking status (yes/no), number of oocytes after the first ovarian stimulation, embryos usable for transfer or cryopreservation after the first cycle, duration of subfertility before treatment and insemination type were used as covariates.
RESULTS: A variation in ongoing pregnancy rates was observed among SES groups after the first fresh embryo transfer. No difference was found in the median number of IVF treatment cycles carried out. The cumulative ongoing pregnancy rates differed significantly between SES groups (low: 44%; medium: 51%; high: 56%; P < 0.001). Low neighbourhood SES was associated with significantly lower odds for achieving an ongoing pregnancy within 2.5 years (OR 0.66, 95% CI 0.52 to 0.84, P < 0.001).
CONCLUSIONS: Low neighbourhood SES compared with high neighbourhood SES is associated with reducing odds of achieving an ongoing pregnancy within 2.5 years of IVF treatment.
METHODS: A retrospective observational study involving 2669 couples who underwent IVF or IVF and intracytoplasmic sperm injection treatment between 2006 and 2020. Neighbourhood SES for each couple was determined based on their residential postal code. Subsequently, SES was categorized into low (
RESULTS: A variation in ongoing pregnancy rates was observed among SES groups after the first fresh embryo transfer. No difference was found in the median number of IVF treatment cycles carried out. The cumulative ongoing pregnancy rates differed significantly between SES groups (low: 44%; medium: 51%; high: 56%; P < 0.001). Low neighbourhood SES was associated with significantly lower odds for achieving an ongoing pregnancy within 2.5 years (OR 0.66, 95% CI 0.52 to 0.84, P < 0.001).
CONCLUSIONS: Low neighbourhood SES compared with high neighbourhood SES is associated with reducing odds of achieving an ongoing pregnancy within 2.5 years of IVF treatment.
摘要：
目的：社区社会经济地位（SES）与IVF治疗2.5年后持续妊娠的累积率之间是否存在关联？
方法：一项回顾性观察研究，涉及2006年至2020年间接受IVF或IVF和胞浆内单精子注射治疗的2669对夫妇。每对夫妇的邻里SES是根据他们的住宅邮政编码确定的。随后，SES被归类为低(p80）。进行了多变量二元逻辑回归分析，以2.5年内的累积持续妊娠为结果变量。SES类别（参考类别：高），女性年龄（参考类别：32-36岁），体重指数（参考类别：23-25kg/m2），吸烟状况（是/否），第一次卵巢刺激后的卵母细胞数量，第一个周期后可用于移植或冷冻保存的胚胎，治疗前的不孕持续时间和授精类型被用作协变量。
结果：在第一次新鲜胚胎移植后，在SES组中观察到持续妊娠率的变化。IVF治疗周期的中位数没有差异。SES组之间的累积持续妊娠率显着差异（低：44％；中：51％；高：56％；P<0.001）。低社区SES与2.5年内实现持续妊娠的几率显著降低相关(OR0.66,95%CI0.52至0.84,P<0.001)。
结论：与高邻域SES相比，低邻域SES与IVF治疗2.5年内实现持续妊娠的几率降低相关。
方法：一项回顾性观察研究，涉及2006年至2020年间接受IVF或IVF和胞浆内单精子注射治疗的2669对夫妇。每对夫妇的邻里SES是根据他们的住宅邮政编码确定的。随后，SES被归类为低(
结果：在第一次新鲜胚胎移植后，在SES组中观察到持续妊娠率的变化。IVF治疗周期的中位数没有差异。SES组之间的累积持续妊娠率显着差异（低：44％；中：51％；高：56％；P<0.001）。低社区SES与2.5年内实现持续妊娠的几率显著降低相关(OR0.66,95%CI0.52至0.84,P<0.001)。
结论：与高邻域SES相比，低邻域SES与IVF治疗2.5年内实现持续妊娠的几率降低相关。
