Abstract：
1,8-Cineole is a bicyclic monoterpene widely distributed in the essential oils of various medicinal plants, and it exhibits significant anti-inflammatory and antioxidant activities. We aimed to investigate the therapeutic effect of 1,8-cineole on anti-Alzheimer\'s disease by using transgenic Caenorhabditis elegans models. Our studies demonstrated that 1,8-cineole significantly relieved Aβ1-42-induced paralysis and exhibited remarkable antioxidant and anti-Aβ1-42 aggregation activities in transgenic nematodes CL4176, CL2006 and CL2355. We developed a 1,8-cineole/cyclodextrin inclusion complex, displaying enhanced anti-paralysis, anti-Aβ aggregation and antioxidant activities compared to 1,8-cineole. In addition, we found 1,8-cineole treatment activated the SKN-1/Nrf-2 pathway and induced autophagy in nematodes. Our results demonstrated the antioxidant and anti-Alzheimer\'s disease activities of 1,8-cineole, which provide a potential therapeutic approach for Alzheimer\'s disease.
摘要：
1,8-桉树脑是一种双环单萜，广泛分布在各种药用植物的精油中，具有显著的抗炎和抗氧化活性。我们旨在通过使用转基因秀丽隐杆线虫模型研究1,8-桉树脑对抗阿尔茨海默病的治疗作用。我们的研究表明，1,8-桉树脑在转基因线虫CL4176，CL2006和CL2355中显着缓解了Aβ1-42诱导的麻痹，并表现出显着的抗氧化和抗Aβ1-42聚集活性。我们开发了一种1,8-桉树脑/环糊精包合物，显示增强的抗麻痹能力，与1,8-桉树脑相比，抗Aβ聚集和抗氧化活性。此外,我们发现1,8-桉树脑处理激活了线虫中的SKN-1/Nrf-2通路并诱导了自噬。我们的结果证明了1,8-桉树脑的抗氧化和抗阿尔茨海默病活性，这为阿尔茨海默病提供了一种潜在的治疗方法。
