PDF(Pubmed)
Abstract：
Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-specific gene expression in mammalian cells. Aberrations in this intricate landscape drive substantial changes in gene function, emerging as a linchpin in cancer etiology and progression. While cancer was conventionally perceived as solely a genetic disorder, its contemporary definition encompasses genetic alterations intertwined with disruptive epigenetic abnormalities. This review explores the profound impact of DNA methylation, histone modifications, and noncoding RNAs on fundamental cellular processes. When these pivotal epigenetic mechanisms undergo disruption, they intricately guide the acquisition of the 6 hallmark characteristics of cancer within seemingly normal cells. Leveraging the latest advancements in decoding these epigenetic intricacies holds immense promise, heralding a new era in developing targeted and more efficacious treatment modalities against cancers driven by aberrant epigenetic modifications.
摘要：
表观遗传机制是细胞正常发育的基石,协调哺乳动物细胞中的组织特异性基因表达。在这个复杂的景观畸变驱动基因功能的实质性变化，成为癌症病因和进展的关键。虽然癌症通常被认为是一种遗传性疾病，其当代定义包括与破坏性表观遗传异常交织在一起的遗传改变。这篇综述探讨了DNA甲基化的深刻影响，组蛋白修饰，和基本细胞过程中的非编码RNA。当这些关键的表观遗传机制受到破坏时，它们错综复杂地引导着在看似正常的细胞中获得癌症的6个标志特征。利用解码这些表观遗传复杂性的最新进展带来了巨大的希望，预示着在开发针对由异常表观遗传修饰驱动的癌症的靶向和更有效的治疗方式方面的新时代。
