PDF(Pubmed)
Abstract：
UNASSIGNED: Mucormycosis is a fatal invasive fungal infection that commonly affects immunocompromised children. The aim of our study was to investigate the clinical manifestations, treatments, and prognosis of pediatric patients with mucormycosis.
UNASSIGNED: We conducted a retrospective search in Shenzhen Children\'s Hospital from July 2013 to July 2023 for all patients with mucormycosis. The clinical manifestation, pathogen detection, radiology, treatments, and prognosis were analyzed.
UNASSIGNED: Four cases were identified. Underlying conditions included acute myeloid leukemia with myeloid sarcoma (n = 1), thalassemia (post-allogeneic hematopoietic stem cell transplantation; n = 1), systemic lupus erythematosus (n = 1), and bilateral nephroblastoma (post-bilateral nephrectomy; n = 1). Two patients were disseminated mucormycosis, one case was pulmonary mucormycosis, and one case was cerebral mucormycosis. Fever, cough, and dyspnea were the main clinical symptoms of pulmonary mucormycosis, headache was the main clinical symptom of cerebral mucormycosis. Lung CT findings included consolidation, multiple nodules, halo sign, air crescent sign, and pleural effusion. The contrast-enhanced CT showed pulmonary artery and pulmonary vein occlusions in two patients and pseudoaneurysm in two patients. Amphotericin B formulations were administered as first-line therapy in all cases; in three cases, Triazole was administered in combination with amphotericin B.
UNASSIGNED: Mucormycosis is a life-threatening disease involving multiple systems. Aorta pseudoaneurysm is a rare and fatal complication, enhanced CT can assist in diagnosis. Early diagnosis and appropriate therapeutic strategies are needed.
UNASSIGNED: We conducted a retrospective search in Shenzhen Children\'s Hospital from July 2013 to July 2023 for all patients with mucormycosis. The clinical manifestation, pathogen detection, radiology, treatments, and prognosis were analyzed.
UNASSIGNED: Four cases were identified. Underlying conditions included acute myeloid leukemia with myeloid sarcoma (n = 1), thalassemia (post-allogeneic hematopoietic stem cell transplantation; n = 1), systemic lupus erythematosus (n = 1), and bilateral nephroblastoma (post-bilateral nephrectomy; n = 1). Two patients were disseminated mucormycosis, one case was pulmonary mucormycosis, and one case was cerebral mucormycosis. Fever, cough, and dyspnea were the main clinical symptoms of pulmonary mucormycosis, headache was the main clinical symptom of cerebral mucormycosis. Lung CT findings included consolidation, multiple nodules, halo sign, air crescent sign, and pleural effusion. The contrast-enhanced CT showed pulmonary artery and pulmonary vein occlusions in two patients and pseudoaneurysm in two patients. Amphotericin B formulations were administered as first-line therapy in all cases; in three cases, Triazole was administered in combination with amphotericin B.
UNASSIGNED: Mucormycosis is a life-threatening disease involving multiple systems. Aorta pseudoaneurysm is a rare and fatal complication, enhanced CT can assist in diagnosis. Early diagnosis and appropriate therapeutic strategies are needed.
摘要：
■毛霉菌病是一种致命的侵袭性真菌感染，通常会影响免疫功能低下的儿童。我们研究的目的是探讨临床表现，治疗,儿童毛霉菌病患者的预后。
■我们于2013年7月至2023年7月在深圳市儿童医院对所有毛霉菌病患者进行了回顾性搜索。临床表现,病原体检测，放射学,治疗,并对预后进行分析。
■确定了4例。基础疾病包括急性髓系白血病伴髓系肉瘤（n=1），地中海贫血（异基因造血干细胞移植后；n=1），系统性红斑狼疮（n=1），和双侧肾母细胞瘤（双侧肾切除术后；n=1）。两名患者为播散性毛霉菌病,1例肺部毛霉菌病,1例脑毛霉菌病。发烧,咳嗽,呼吸困难是肺毛霉菌病的主要临床症状，头痛是脑毛霉菌病的主要临床症状。肺部CT表现包括实变，多发结节,光环标志,空气新月标志，和胸腔积液.对比增强CT显示2例患者有肺动脉和肺静脉阻塞，2例患者有假性动脉瘤。两性霉素B制剂在所有病例中作为一线治疗给药；在3例病例中，三唑与两性霉素B联合给药。
■毛霉菌病是一种涉及多个系统的危及生命的疾病。主动脉假性动脉瘤是一种罕见且致命的并发症，增强CT可以辅助诊断。需要早期诊断和适当的治疗策略。
■我们于2013年7月至2023年7月在深圳市儿童医院对所有毛霉菌病患者进行了回顾性搜索。临床表现,病原体检测，放射学,治疗,并对预后进行分析。
■确定了4例。基础疾病包括急性髓系白血病伴髓系肉瘤（n=1），地中海贫血（异基因造血干细胞移植后；n=1），系统性红斑狼疮（n=1），和双侧肾母细胞瘤（双侧肾切除术后；n=1）。两名患者为播散性毛霉菌病,1例肺部毛霉菌病,1例脑毛霉菌病。发烧,咳嗽,呼吸困难是肺毛霉菌病的主要临床症状，头痛是脑毛霉菌病的主要临床症状。肺部CT表现包括实变，多发结节,光环标志,空气新月标志，和胸腔积液.对比增强CT显示2例患者有肺动脉和肺静脉阻塞，2例患者有假性动脉瘤。两性霉素B制剂在所有病例中作为一线治疗给药；在3例病例中，三唑与两性霉素B联合给药。
■毛霉菌病是一种涉及多个系统的危及生命的疾病。主动脉假性动脉瘤是一种罕见且致命的并发症，增强CT可以辅助诊断。需要早期诊断和适当的治疗策略。
