PDF(Pubmed)
Abstract：
BACKGROUND: Rotavirus has a significant morbidity and mortality in children under two years. The burden of rotavirus diarrhea 4 years post introduction of rotavirus vaccine in Uganda is not well established. This study aimed to determine the prevalence, severity of dehydration and factors associated with rotavirus diarrhea among children aged 3 to 24 months after the introduction of the vaccine at Fort Portal Regional Referral hospital.
METHODS: This was a cross-sectional hospital-based study in which children with acute watery diarrhea were included. A rectal tube was used to collect a stool sample for those unable to provide samples. Stool was tested for rotavirus using rapid immunochromatographic assay. Data was analysed using SPSS version 22 with logistic regression done to determine the factors.
RESULTS: Out of 268 children with acute watery diarrhea, 133 (49.6%) were females. Rotavirus test was positive in 42 (15.7%), majority of whom had some dehydration 28(66.7%). The factors that were independently associated with rotavirus diarrhea were; age < 12 months (AOR = 8.87, P = 0.014), male gender (AOR = 0.08, P = 0.001), coming from a home with another person with diarrhea (AOR = 17.82, P = 0.001) or a home where the water source was a well (AOR = 50.17, P = 0.002).
CONCLUSIONS: The prevalence of rotavirus diarrhea was three times less in the post rotavirus vaccination period compared to pre-rota vaccination period. Majority of the participants with rotavirus diarrhea had some dehydration. There is need for provision of safe water sources to all homes. Surveillance to determine the cause of the non rota diarrhea should be done.
METHODS: This was a cross-sectional hospital-based study in which children with acute watery diarrhea were included. A rectal tube was used to collect a stool sample for those unable to provide samples. Stool was tested for rotavirus using rapid immunochromatographic assay. Data was analysed using SPSS version 22 with logistic regression done to determine the factors.
RESULTS: Out of 268 children with acute watery diarrhea, 133 (49.6%) were females. Rotavirus test was positive in 42 (15.7%), majority of whom had some dehydration 28(66.7%). The factors that were independently associated with rotavirus diarrhea were; age < 12 months (AOR = 8.87, P = 0.014), male gender (AOR = 0.08, P = 0.001), coming from a home with another person with diarrhea (AOR = 17.82, P = 0.001) or a home where the water source was a well (AOR = 50.17, P = 0.002).
CONCLUSIONS: The prevalence of rotavirus diarrhea was three times less in the post rotavirus vaccination period compared to pre-rota vaccination period. Majority of the participants with rotavirus diarrhea had some dehydration. There is need for provision of safe water sources to all homes. Surveillance to determine the cause of the non rota diarrhea should be done.
摘要：
背景：轮状病毒在两岁以下儿童中具有显著的发病率和死亡率。在乌干达引入轮状病毒疫苗后4年轮状病毒腹泻的负担尚未完全确定。这项研究旨在确定患病率，FortPortal地区转诊医院接种疫苗后3~24个月儿童的脱水严重程度和轮状病毒腹泻相关因素。
方法：这是一项基于医院的横断面研究，其中包括急性水样腹泻患儿。使用直肠管收集无法提供样品的粪便样品。使用快速免疫层析法检测粪便中的轮状病毒。使用SPSS版本22对数据进行分析，并进行逻辑回归以确定因素。
结果：在268例急性水样腹泻患儿中，133（49.6％）为女性。轮状病毒检测阳性42例(15.7%),其中大多数人有些脱水28（66.7％）。与轮状病毒腹泻独立相关的因素是；年龄<12个月（AOR=8.87，P=0.014）。男性(AOR=0.08,P=0.001),来自另一个患有腹泻的人的家庭（AOR=17.82，P=0.001）或水源为井的家庭（AOR=50.17，P=0.002）。
结论：与轮状病毒疫苗接种前相比，轮状病毒疫苗接种后轮状病毒腹泻的患病率低三倍。大多数轮状病毒腹泻的参与者有一些脱水。需要向所有家庭提供安全的水源。应进行监测以确定非轮状病毒腹泻的原因。
方法：这是一项基于医院的横断面研究，其中包括急性水样腹泻患儿。使用直肠管收集无法提供样品的粪便样品。使用快速免疫层析法检测粪便中的轮状病毒。使用SPSS版本22对数据进行分析，并进行逻辑回归以确定因素。
结果：在268例急性水样腹泻患儿中，133（49.6％）为女性。轮状病毒检测阳性42例(15.7%),其中大多数人有些脱水28（66.7％）。与轮状病毒腹泻独立相关的因素是；年龄<12个月（AOR=8.87，P=0.014）。男性(AOR=0.08,P=0.001),来自另一个患有腹泻的人的家庭（AOR=17.82，P=0.001）或水源为井的家庭（AOR=50.17，P=0.002）。
结论：与轮状病毒疫苗接种前相比，轮状病毒疫苗接种后轮状病毒腹泻的患病率低三倍。大多数轮状病毒腹泻的参与者有一些脱水。需要向所有家庭提供安全的水源。应进行监测以确定非轮状病毒腹泻的原因。
