Abstract：
Lactobacillus plantarum has been shown to improve glucose and lipid metabolism in mouse models of type 2 diabetes mellitus (T2DM). However, it remains unclear whether such benefits extend to humans. A systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to clarify the effect of L. plantarum supplementation on glucose and lipid metabolism in T2DM and prediabetes. The PubMed, Cochrane, and Web of Science databases were searched. A random-effects model was used to estimate the pooled mean difference with 95% CI (confidence interval). L. plantarum supplementation reduced the levels of fasting plasma glucose (-0.41, 95%CI -0.63, -0.19 mg/dL; n = 5) and hemoglobin A1c (-0.2, 95%CI: -0.3, 0%; n = 4). A non-statistically significant tendency towards improvements in the Homeostatic Model Assessment for Insulin Resistance (MD: -0.74, 95%CI: -1.72, 0.25; n = 3), low-density lipoprotein cholesterol (-6.87; 95%CI: -15.03, 1.29 mg/dL; n = 3), high-density lipoprotein cholesterol (MD: 1.34; 95%CI: -0.78, 3.46 mg/dL; n = 3), triglyceride (MD: -3.90; 95%CI: -11.05, 3.24 mg/dL; n = 3), and total cholesterol (MD: -4.88; 95%CI: -11.84, 2.07 mg/dL; n = 3) was observed with the supplementation. In summary, while the evidence from the currently available RCTs provides a crude indication that L. plantarum supplementation might improve glucose and lipid metabolism in patients with T2DM and prediabetes, the benefits of the supplementation are likely subtle, and its clinical significance requires further investigation.
摘要：
植物乳杆菌已被证明可以改善2型糖尿病（T2DM）小鼠模型中的葡萄糖和脂质代谢。然而,目前尚不清楚这种益处是否适用于人类。对随机对照试验（RCT）进行了系统评价和荟萃分析，以阐明补充植物乳杆菌对T2DM和糖尿病前期患者糖脂代谢的影响。PubMed,科克伦,搜索了WebofScience数据库。使用随机效应模型以95%CI(置信区间)估计合并平均差。补充植物乳杆菌可降低空腹血糖水平(-0.41,95CI-0.63,-0.19mg/dL;n=5)和血红蛋白A1c(-0.2,95CI:-0.3,0%;n=4)。胰岛素抵抗稳态模型评估的改善趋势无统计学意义（MD：-0.74，95CI：-1.72，0.25；n=3），低密度脂蛋白胆固醇（-6.87；95CI：-15.03，1.29mg/dL；n=3），高密度脂蛋白胆固醇（MD：1.34;95CI：-0.78,3.46mg/dL;n=3），甘油三酯（MD：-3.90；95CI：-11.05，3.24mg/dL；n=3），和总胆固醇(MD:-4.88;95CI:-11.84,2.07mg/dL;n=3)。总之,而来自现有RCT的证据表明，植物乳杆菌补充剂可能改善T2DM和糖尿病前期患者的糖脂代谢，补充剂的好处可能是微妙的，其临床意义需要进一步研究。
