Abstract：
Lysergic acid diethylamide (LSD) and two phenethylamine classes (NBOHs and NBOMes) are the main illicit drugs found in seized blotter papers. The preliminary identification of these substances is of great interest for forensic analysis. In this context, this work constitutes the inaugural demonstration of an efficient methodology for the selective detection of LSD, NBOHs, and NBOMes, utilizing a fully 3D-printed electrochemical double cell (3D-EDC). This novel 3D-EDC enables the use of two working electrodes and/or two supporting electrolytes (at different pHs) in the same detection system, with the possibility of shared or individual auxiliary and pseudo-reference electrodes. Thus, the selective voltammetric detection of these substances is proposed using two elegant strategies: (i) utilizing the same 3D-EDC platform with two working electrodes (boron-doped diamond (BDD) and 3D-printed graphite), and (ii) employing two pH levels (4.0 and 12.0) with 3D-printed graphite electrode. This comprehensive framework facilitates a fast, robust, and uncomplicated electrochemical analysis. Moreover, this configuration enables a rapid and sensitive detection of LSD, NBOHs, and NBOMes in seized samples, and can also provide quantitative analysis. The proposed method showed good stability of the electrochemical response with RSD <9 % for Ip and <5 % for Ep, evaluating all oxidation processes observed for studied analytes (n = 7) at two pH levels, using the same and different (n = 3) working electrodes. It demonstrates a broad linear range (20-100 and 20-70 μmol L-1) and a low LOD (1.0 μmol L-1) for quantification of a model molecule (LSD) at the two pHs studied. Hence, the 3D-EDC combined with voltammetric techniques using BDD and 3D-printed graphite electrodes on the same platform, or only with this last sensor at two pH values, provide a practical and robust avenue for preliminary identification of NBOHs, NBOMes, and LSD. This method embodies ease, swiftness, cost-efficiency, robustness, and selectivity as an on-site screening tool for forensic analysis.
摘要：
麦角酰二乙胺（LSD）和两种苯乙胺类（NBOHs和NBOMes）是在缉获的吸墨纸中发现的主要非法药物。这些物质的初步鉴定对于法医分析非常有意义。在这种情况下，这项工作构成了选择性检测LSD的有效方法的首次演示，NBOHs,和NBOMes，利用完全3D打印的电化学双电池（3D-EDC）。这种新颖的3D-EDC能够在同一检测系统中使用两个工作电极和/或两个支持电解质（在不同的pH下）。与共享或单独的辅助和伪参考电极的可能性。因此，使用两种优雅的策略提出了对这些物质的选择性伏安检测：（i）利用具有两个工作电极（掺硼金刚石（BDD）和3D打印石墨）的相同3D-EDC平台，和(ii)使用3D打印石墨电极使用两个pH水平(4.0和12.0)。这个全面的框架有助于快速、健壮,和简单的电化学分析。此外，这种配置可以快速、灵敏地检测LSD，NBOHs,以及检获样本中的NBOMes,还可以提供定量分析。所提出的方法显示出良好的电化学响应稳定性，Ip的RSD<9％，Ep的RSD<5％，评估在两个pH水平下观察到的被研究分析物（n=7）的所有氧化过程，使用相同和不同的（n=3）工作电极。它显示了在所研究的两个pH下定量模型分子（LSD）的宽线性范围（20-100和20-70μmolL-1）和低LOD（1.0μmolL-1）。因此，3D-EDC结合伏安技术使用BDD和3D打印石墨电极在同一平台上，或仅在两个pH值下使用最后一个传感器，为NBOHs的初步鉴定提供了一个实用和可靠的途径，NBOMes,LSD。这种方法体现了轻松，迅速,成本效益，鲁棒性，和选择性作为法医分析的现场筛选工具。
