Abstract：
Varicocele (VC) is a common cause of infertility in men. Pathophysiological changes caused by VC, such as testicular hypoxia, high temperatures, oxidative stress, abnormal reproductive hormones, and Cd accumulation, can induce autophagy, thus affecting the reproductive function in patients with this condition. Autophagy regulators can be classified as activators or inhibitors. Autophagy activators upregulate autophagy, reduce the damage to the testis and epididymis, inhibit spermatogenic cell apoptosis, and protect fertility. In contrast, autophagy inhibitors block autophagy and aggravate the damage to the reproductive functions. Therefore, elucidating the role of autophagy in the occurrence, development, and regulation of VC may provide additional therapeutic options for men with infertility and VC. In this review, we briefly describe the progress made in autophagy research in the context of VC.
摘要：
精索静脉曲张（VC）是男性不育的常见原因。VC引起的病理生理变化，如睾丸缺氧，高温,氧化应激，生殖激素异常,和Cd积累，可以诱导自噬，从而影响患者的生殖功能。自噬调节剂可分为激活剂或抑制剂。自噬激活剂上调自噬，减少对睾丸和附睾的损伤，抑制生精细胞凋亡，保护生育能力。相比之下,自噬抑制剂阻断自噬，加重对生殖功能的损害。因此,阐明自噬在发生中的作用，发展,和VC的调节可能为不育和VC的男性提供额外的治疗选择。在这次审查中,我们简要描述了在VC背景下自噬研究的进展。
