Abstract：
Phosphoinositide 3-kinases regulate many cellular functions, including migration, growth, proliferation, and cell survival. Early studies equated the inhibition of Class I PI3Ks with loss of; phosphatidylinositol 3,4,5-trisphosphate (PIP3), but over time, it was realised that these; treatments also depleted phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). In recent years, the; use of better tools and an improved understanding of its metabolism have allowed for the; identification of specific roles of PI(3,4)P2. This includes the production of PI(3,4)P2 and the; activation of its effector Akt2 in response to growth factor signalling. In contrast, a lysosomal pool of PI(3,4)P2 is a negative regulator of mTORC1 during growth factor deprivation. A growing body of literature also demonstrates that PI(3,4)P2 controls many dynamic plasmalemmal processes. The significance of PI(3,4)P2 in cell biology is increasingly evident.
摘要：
磷酸肌醇3-激酶调节许多细胞功能，包括迁移，增长,扩散,细胞存活。早期研究将I类PI3K的抑制等同于磷脂酰肌醇3,4,5-三磷酸（PIP3），但随着时间的推移,人们认识到,这些处理也耗尽了磷脂酰肌醇3,4-二磷酸(PI(3,4)P2)。近年来,使用更好的工具和对其代谢的更好理解已经允许识别PI（3,4）P2的特定作用。这包括响应于生长因子信号传导的PI(3,4)P2的产生和其效应物Akt2的激活。相比之下,PI(3,4)P2的溶酶体池是生长因子剥夺期间mTORC1的负调节因子。越来越多的文献还表明，PI（3,4）P2控制许多动态质膜过程。PI(3,4)P2在细胞生物学中的意义日益明显。
