Abstract：
Accumulation of pathogenic factors in the blood may cause irreversible damage and may even be life-threatening. Hemoperfusion is an effective technique for eliminating pathogenic factors, which is widely used in the treatment of various diseases including liver failure, renal failure, sepsis, and others. Hemoperfusion adsorbents are crucial in this process as they specifically bind and remove the target pathogenic factors. This review describes the development of hemoperfusion adsorbents, detailing the different properties exhibited by inorganic materials, organic polymers, and new materials. Advances in natural and synthetic polymers and novel materials manufacturing techniques have driven the expansion of hemoperfusion adsorbents in clinical applications. Stimuli-responsive (smart responsive) adsorbents with controllable molecular binding properties have many promising and environmentally friendly biomedical applications. Knowledge gaps, future research directions, and prospects for hemoperfusion adsorbents are discussed.
摘要：
血液中致病因素的积累可能会导致不可逆转的损害，甚至可能危及生命。血液灌流是消除致病因素的有效技术,广泛用于治疗各种疾病，包括肝功能衰竭，肾功能衰竭,脓毒症,和其他人。血液灌流吸附剂在此过程中至关重要，因为它们特异性结合并去除目标致病因子。本文综述了血液灌流吸附剂的发展，详述无机材料表现出的不同性质，有机聚合物,和新材料。天然和合成聚合物以及新材料制造技术的进步推动了血液灌流吸附剂在临床应用中的扩展。具有可控分子结合特性的刺激响应(智能响应)吸附剂具有许多有前途的和环境友好的生物医学应用。知识差距,未来的研究方向，并讨论了血液灌流吸附剂的前景。
