Abstract：
Observational studies have linked selenium and metabolic syndrome (MetS), but the causality remains unclear. Therefore, this study intends to determine the causal relationship between selenium and the risk of MetS and its component features [body mass index (BMI), waist circumference adjusted for BMI (WCadjBMI), triglycerides (TC), HDL-cholesterol (HDL-C), fasting blood glucose (FBG), fasting blood insulin (FBI), systolic blood pressure (SBP), and diastolic blood pressure (DBP)]. This study was designed as the two-sample Mendelian randomization (MR), and genetic variants were obtained from the genome-wide association studies. The inverse variance weighted (IVW) was applied as the primary method, and the MR-Egger, weighted median, and MR-PRESSO were supplemented to assess its robustness. The Bonferroni method was used to correct p-values for multiple tests. Genetically incremented selenium level was related to higher odds ratios of developing the MetS (OR = 1.054, 95% CI = 1.016-1.094, p = 0.0049). As for components, significant causal links were identified between selenium and BMI (β = 0.015, p = 1.321 × 10-5), WCadjBMI (β = 0.033, p = 2.352 × 10-4), HDL-C (β = -0.036, p = 1.352 × 10-8), FBG (β = 0.028, p = 0.001), and FBI (β = 0.028, p = 0.002). No significant association was discovered for SBP (β = -0.076, p = 0.218) and DBP (β = 0.054, p = 0.227). These results were generally supported by the weighted median and MR-PRESSO methods. Our study provided evidence of the causal effect of selenium on MetS risk from the genetic perspective in the European population, and further investigation across diverse populations was warranted.
摘要：
观察性研究已将硒与代谢综合征（MetS）联系起来，但因果关系尚不清楚。因此,这项研究旨在确定硒与MetS风险之间的因果关系及其组成特征[体重指数（BMI），根据BMI（WCadjBMI）调整腰围，甘油三酯（TC），HDL-胆固醇(HDL-C)空腹血糖（FBG），空腹血胰岛素（FBI），收缩压（SBP），和舒张压（DBP）]。本研究设计为两个样本孟德尔随机化(MR)，和遗传变异是从全基因组关联研究中获得的。应用逆方差加权(IVW)作为主要方法，和MR-Egger，加权中位数，和MR-PRESSO进行了补充，以评估其稳健性。Bonferroni方法用于校正多次测试的p值。遗传增加的硒水平与发展MetS的比值比更高有关（OR=1.054，95％CI=1.016-1.094，p=0.0049）。至于组件，硒与BMI之间存在显著的因果关系(β=0.015，p=1.321×10-5)，WCadjBMI（β=0.033，p=2.352×10-4），HDL-C（β=-0.036，p=1.352×10-8），FBG(β=0.028,p=0.001),和FBI(β=0.028,p=0.002)。未发现SBP（β=-0.076，p=0.218）和DBP（β=0.054，p=0.227）的显着相关性。这些结果通常得到加权中位数和MR-PRESSO方法的支持。我们的研究从欧洲人群的遗传角度提供了硒对MetS风险的因果影响的证据，需要对不同人群进行进一步调查.
