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Abstract：
OBJECTIVE: Familial Mediterranean fever is the most common monogenic autoinflammatory disease. This study aimed to evaluate the relationship between sacroiliitis observed in familial Mediterranean fever and hematological inflammatory markers.
METHODS: In this study, 168 familial Mediterranean fever patients were examined. A total of 61 familial Mediterranean fever patients who had sacroiliac magnetic resonance imaging due to waist and hip pain were included in the study. According to the magnetic resonance imaging findings, patients were divided into two groups: with and without sacroiliitis. The relationship between hematological inflammatory markers and sacroiliitis was investigated.
RESULTS: The frequency of sacroiliitis was found to be 13.6% in all familial Mediterranean fever patients and 37.8% in patients with low back pain who underwent sacroiliac magnetic resonance imaging. Neutrophil count, neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune-inflammatory index were significantly higher in the sacroiliitis group than in the other group, and this difference was found to be statistically significant (p<0.05). As a result of the receiver operating characteristic analysis, it was observed that neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune-inflammatory index were very sensitive parameters in determining sacroiliitis in patients with familial Mediterranean fever.
CONCLUSIONS: It was observed that the frequency of sacroiliitis was increased in familial Mediterranean fever patients. It is predicted that hematological inflammatory markers such as neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune-inflammatory index can be used in the diagnosis of sacroiliitis.
METHODS: In this study, 168 familial Mediterranean fever patients were examined. A total of 61 familial Mediterranean fever patients who had sacroiliac magnetic resonance imaging due to waist and hip pain were included in the study. According to the magnetic resonance imaging findings, patients were divided into two groups: with and without sacroiliitis. The relationship between hematological inflammatory markers and sacroiliitis was investigated.
RESULTS: The frequency of sacroiliitis was found to be 13.6% in all familial Mediterranean fever patients and 37.8% in patients with low back pain who underwent sacroiliac magnetic resonance imaging. Neutrophil count, neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune-inflammatory index were significantly higher in the sacroiliitis group than in the other group, and this difference was found to be statistically significant (p<0.05). As a result of the receiver operating characteristic analysis, it was observed that neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune-inflammatory index were very sensitive parameters in determining sacroiliitis in patients with familial Mediterranean fever.
CONCLUSIONS: It was observed that the frequency of sacroiliitis was increased in familial Mediterranean fever patients. It is predicted that hematological inflammatory markers such as neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune-inflammatory index can be used in the diagnosis of sacroiliitis.
摘要：
目的：家族性地中海热是最常见的单基因自身炎症性疾病。本研究旨在评估家族性地中海热中观察到的骶髂关节炎与血液炎症标志物之间的关系。
方法：在本研究中，对168例家族性地中海热患者进行了检查。共有61名家族性地中海热患者因腰部和臀部疼痛而进行骶髂磁共振成像。根据磁共振成像的发现,患者分为两组:有和没有骶髂关节炎.研究了血液炎症标志物与骶髂关节炎的关系。
结果：在所有家族性地中海热患者中，骶髂关节炎的发生率为13.6%，在接受骶髂磁共振成像的下腰痛患者中，骶髂关节炎的发生率为37.8%。中性粒细胞计数,中性粒细胞/淋巴细胞比率，单核细胞/淋巴细胞比率，骶髂关节炎组的全身免疫炎症指数明显高于其他组，发现这种差异具有统计学意义（p<0.05）。作为接收机工作特性分析的结果，观察到中性粒细胞/淋巴细胞比率，单核细胞/淋巴细胞比率，和全身免疫炎症指数是确定家族性地中海热患者骶髂关节炎的非常敏感的参数。
结论：观察到家族性地中海热患者骶髂关节炎的频率增加。预测血液炎症标志物如中性粒细胞/淋巴细胞比率，单核细胞/淋巴细胞比率，全身免疫炎症指标可用于骶髂关节炎的诊断。
方法：在本研究中，对168例家族性地中海热患者进行了检查。共有61名家族性地中海热患者因腰部和臀部疼痛而进行骶髂磁共振成像。根据磁共振成像的发现,患者分为两组:有和没有骶髂关节炎.研究了血液炎症标志物与骶髂关节炎的关系。
结果：在所有家族性地中海热患者中，骶髂关节炎的发生率为13.6%，在接受骶髂磁共振成像的下腰痛患者中，骶髂关节炎的发生率为37.8%。中性粒细胞计数,中性粒细胞/淋巴细胞比率，单核细胞/淋巴细胞比率，骶髂关节炎组的全身免疫炎症指数明显高于其他组，发现这种差异具有统计学意义（p<0.05）。作为接收机工作特性分析的结果，观察到中性粒细胞/淋巴细胞比率，单核细胞/淋巴细胞比率，和全身免疫炎症指数是确定家族性地中海热患者骶髂关节炎的非常敏感的参数。
结论：观察到家族性地中海热患者骶髂关节炎的频率增加。预测血液炎症标志物如中性粒细胞/淋巴细胞比率，单核细胞/淋巴细胞比率，全身免疫炎症指标可用于骶髂关节炎的诊断。
