Abstract：
Diabetes mellitus is a metabolic disease associated with hyperglycemia caused by insufficient insulin secretion or insulin resistance. Early symptoms are related to an abnormal increase in water intake, food intake, and urination. In Chinese medicine, diabetes mellitus is categorized as a \"thirst-quenching\" condition. Currently, the clinical treatment of diabetes mellitus relies mainly on Western medications, which often target the symptoms rather than alter the cause of the disease, and can cause certain side effects and drug resistance. In comparison, the polysaccharides of Chinese medicines from the same source of food and medicine have become an emerging choice for the prevention and treatment of diabetes due to their wide sources, high safety, and low side effects. To reveal the mechanisms of the polysaccharides of traditional Chinese medicine (TCM) in the prevention and treatment of diabetes mellitus, the CiteSpace visualization software was used to conduct extensive literature searches through Chinese and international databases, such as PubMed, Medline, and China National Knowledge Infrastructure. Through literature volume analysis, keyword co-occurrence, cluster analysis, and trend highlighting, we found that the main mechanisms of TCM polysaccharides in the prevention and treatment of diabetes include regulating intestinal flora, improving insulin resistance, alleviating oxidative stress, adjusting lipid metabolism imbalance, and inhibiting inflammatory responses. Furthermore, this study systematically summarizes the mechanism of \"using sugar to reduce sugar\" to provide innovative ideas for the development of health products for the treatment of diabetes using the polysaccharides of Chinese medicinal herbs.
摘要：
糖尿病是由胰岛素分泌不足或胰岛素抵抗引起的与高血糖相关的代谢性疾病。早期症状与水摄入量异常增加有关，食物摄入量,和排尿。在中医方面，糖尿病被归类为“解渴”疾病。目前,糖尿病的临床治疗主要依靠西药,通常针对症状而不是改变疾病的原因，并可引起一定的副作用和耐药性。相比之下,来自同一食品和药品的中药多糖由于其来源广泛，已成为预防和治疗糖尿病的新兴选择，安全性高,和低副作用。探讨中药多糖防治糖尿病的作用机制,CiteSpace可视化软件用于通过中国和国际数据库进行广泛的文献检索，比如PubMed,Medline,和中国国家知识基础设施。通过文献量分析,关键字共现，聚类分析,趋势突出，发现中药多糖防治糖尿病的主要机制包括调节肠道菌群,改善胰岛素抵抗，缓解氧化应激，调节脂质代谢失衡，抑制炎症反应。此外，本研究系统总结了"以糖降糖"的作用机理,为开发中药多糖治疗糖尿病的保健品提供创新思路。
